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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Elevated Risk for HIV-1 Infection in Adolescents and Young Adults in Sao Paulo, Brazil

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Autor(es):
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Bassichetto, Katia Cristina [1] ; Bergamaschi, Denise Pimentel [2] ; Oliveira, Solange Maria [3] ; Verri Deienno, Marylei Casteldelli [4] ; Bortolato, Reginaldo [5] ; de Rezende, Heloiza Vilma [6] ; Arthur, Thais [2] ; Tomiyama, Helena [7] ; Watkins, Colyn [7] ; Mesquita, Fabio [1] ; Abbate, Maria Cristina [1] ; Kallas, Esper Georges [7, 2]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Publ Hlth Dept Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Allergy & Immunol, Sao Paulo - Brazil
[3] Henfil Counseling & Testing Ctr, Sao Paulo - Brazil
[4] Spec Attend Serv STD Aids Camp Eliseos, Sao Paulo - Brazil
[5] Spec Attend Serv STD Aids Lapa, Sao Paulo - Brazil
[6] Pirituba Counsel & Test Ctr, Sao Paulo - Brazil
[7] Univ Fed Sao Paulo, Div Infect Dis, Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 3, n. 1, p. 0-0, Jan. 2008.
Área do conhecimento: Ciências da Saúde - Medicina
Notas: Revista de acesso aberto, artigo número e1423
Citações Web of Science: 9
Assunto(s):Doenças virais sexualmente transmissíveis   Infecções por HIV   Educação sexual   Preconceito   Medição de risco
Resumo

Recent studies have sought to describe HIV infection and transmission characteristics around the world. Identification of early HIV-1 infection is essential to proper surveillance and description of regional transmission trends. In this study we compare people recently infected (RI) with HIV-1, as defined by Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS), to those with chronic infection. Subjects were identified from 2002-2004 at four testing sites in São Paulo. Of 485 HIV-1-positive subjects, 57 (12%) were defined as RI. Of the participants, 165 (34.0%) were aware of their serostatus at the time of HIV-1 testing. This proportion was statistically larger (p<0.001) among the individuals without recent infection (n = 158, 95.8%) compared to 7 individuals (4.2%) with recently acquired HIV-1 infection. In the univariate analysis, RI was more frequent in <25 and >59 years-old age strata (p<0.001). The majority of study participants were male (78.4%), 25 to 45 years-old (65.8%), white (63.2%), single (61.7%), with family income of four or more times the minimum wage (41.0%), but with an equally distributed educational level. Of those individuals infected with HIV-1, the predominant route of infection was sexual contact (89.4%), with both hetero (47.5%) and homosexual (34.5%) exposure. Regarding sexual activity in these individuals, 43.9% reported possible HIV-1 exposure through a seropositive partner, and 49.4% reported multiple partners, with 47% having 2 to 10 partners and 37.4% 11 or more; 53.4% of infected individuals reported condom use sometimes; 34.2% reported non-injecting, recreational drug use and 23.6% were reactive for syphilis by VDRL. Subjects younger than 25 years of age were most vulnerable according to the multivariate analysis. In this study, we evaluated RI individuals and discovered that HIV-1 has been spreading among younger individuals in São Paulo and preventive approaches should, therefore, target this age stratum. (AU)

Processo FAPESP: 04/15856-9 - Análise prospectiva das características virológicas e imunológicas em indivíduos com infecção recente pelo HIV-1 das cidades de São Paulo e Santos, SP
Beneficiário:Ricardo Sobhie Diaz
Modalidade de apoio: Auxílio à Pesquisa - Temático