Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection

Autor(es)

Brassesco, Maria Sol ^{[1, 2]} ; Darrigo, Jr., Luiz Guilherme ^[1] ; Valera, Elvis Terci ^[1] ; Oliveira, Ricardo Santos ^[3] ; Yamamoto, Yulie Aparecida ^[1] ; de Castro Barros, Marcus Vinicius ^[4] ; Tone, Luiz Gonzaga ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Pediat Lab, Hosp Clin, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Surg & Anat, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHILD'S NERVOUS SYSTEM; v. 29, n. 8, p. 1387-1390, AUG 2013.
• Citações Web of Science: 3

Resumo

John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors. We present a unique clinical case of an HIV-positive pediatric patient with multifocal leukoencephalopathy and confirmed JC virus (JCV) infection that developed a giant-cell glioblastoma. Experimental data with infected primates has previously hypothesized an association of human giant-cell glioblastoma with JCV or progressive multifocal leukoencephalopathy, though such association has not been documented in the literature for humans. Future studies with larger cohorts and molecular pathological analyses are still needed to corroborate the role of the widely spread human neurotropic virus in early transformation and in the development of brain tumors with different histology in the setting of HIV-related severe immunosuppression. (AU)

• Processo FAPESP: 10/15717-0 - Análise de aberrações cromossômicas em neoplasias da Infância através de citogenética convencional e Hibridização in situ fluorescente (FISH)
• Beneficiário: Elvis Terci Valera
• Modalidade de apoio: Auxílio à Pesquisa - Regular