Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection

Author(s)

Brassesco, Maria Sol ^{[1, 2]} ; Darrigo, Jr., Luiz Guilherme ^[1] ; Valera, Elvis Terci ^[1] ; Oliveira, Ricardo Santos ^[3] ; Yamamoto, Yulie Aparecida ^[1] ; de Castro Barros, Marcus Vinicius ^[4] ; Tone, Luiz Gonzaga ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Pediat Lab, Hosp Clin, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Surg & Anat, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, BR-14048900 Sao Paulo - Brazil

• Document type: Journal article
• Source: CHILD'S NERVOUS SYSTEM; v. 29, n. 8, p. 1387-1390, AUG 2013.
• Web of Science Citations: 3

Abstract

John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors. We present a unique clinical case of an HIV-positive pediatric patient with multifocal leukoencephalopathy and confirmed JC virus (JCV) infection that developed a giant-cell glioblastoma. Experimental data with infected primates has previously hypothesized an association of human giant-cell glioblastoma with JCV or progressive multifocal leukoencephalopathy, though such association has not been documented in the literature for humans. Future studies with larger cohorts and molecular pathological analyses are still needed to corroborate the role of the widely spread human neurotropic virus in early transformation and in the development of brain tumors with different histology in the setting of HIV-related severe immunosuppression. (AU)

• FAPESP's process: 10/15717-0 - Analysis of chromosomal aberrations in childhood cancer through conventional and molecular cytogenetics
• Grantee: Elvis Terci Valera
• Support Opportunities: Regular Research Grants