| Texto completo | |
| Autor(es): |
Bragatto, Felipe Barca
[1, 2]
;
Barbosa, Caio Parente
[1]
;
Christofolini, Denise Maria
[1]
;
Peluso, Carla
[1]
;
dos Santos, Aline Amaro
[1]
;
Mafra, Fernanda Abani
[1]
;
Cavalcanti, Viviane
[1]
;
Hix, Sonia
[2]
;
Bianco, Bianca
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Fac Med ABC, Dept Gynecol & Obstet, Human Reprod & Genet Ctr, Santo Andre, SP - Brazil
[2] Fac Med ABC, Dept Morphol, Div Biochem, Santo Andre, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Reproductive Health; v. 10, JUN 22 2013. |
| Citações Web of Science: | 4 |
| Resumo | |
Background: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). Methods: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. Results: The paraoxonase activity were 191.29 +/- 22.41 U/l in women with minimal/mild endometriosis and 224.85 +/- 21.50 U/l in women with moderate/ severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 +/- 4.61 U/l in women with minimal/mild endometriosis and 90.78 +/- 3.43 U/l in moderate/ severe disease (P = 0.888). Conclusions: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis. (AU) | |
| Processo FAPESP: | 13/12427-9 - There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study |
| Beneficiário: | Bianca Alves Vieira Bianco |
| Modalidade de apoio: | Auxílio à Pesquisa - Publicações científicas - Artigo |