There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

Author(s)

Bragatto, Felipe Barca ^{[1, 2]} ; Barbosa, Caio Parente ^[1] ; Christofolini, Denise Maria ^[1] ; Peluso, Carla ^[1] ; dos Santos, Aline Amaro ^[1] ; Mafra, Fernanda Abani ^[1] ; Cavalcanti, Viviane ^[1] ; Hix, Sonia ^[2] ; Bianco, Bianca ^[1]

Affiliation

^[1] Fac Med ABC, Dept Gynecol & Obstet, Human Reprod & Genet Ctr, Santo Andre, SP - Brazil

^[2] Fac Med ABC, Dept Morphol, Div Biochem, Santo Andre, SP - Brazil

• Document type: Journal article
• Source: Reproductive Health; v. 10, JUN 22 2013.
• Web of Science Citations: 4

Abstract

Background: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). Methods: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. Results: The paraoxonase activity were 191.29 +/- 22.41 U/l in women with minimal/mild endometriosis and 224.85 +/- 21.50 U/l in women with moderate/ severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 +/- 4.61 U/l in women with minimal/mild endometriosis and 90.78 +/- 3.43 U/l in moderate/ severe disease (P = 0.888). Conclusions: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis. (AU)

• FAPESP's process: 13/12427-9 - There is no relationship between paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study
• Grantee: Bianca Alves Vieira Bianco
• Support Opportunities: Regular Research Grants - Publications - Scientific article