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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

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Autor(es):
Bragatto, Felipe Barca [1, 2] ; Barbosa, Caio Parente [2] ; Christofolini, Denise Maria [2] ; Peluso, Carla [2] ; dos Santos, Aline Amaro [2] ; Mafra, Fernanda Abani [2] ; Cavalcanti, Viviane [2] ; Hix, Sonia [1] ; Bianco, Bianca [2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Fac Med ABC, Dept Morphol, Div Biochem, Santo Andre, SP - Brazil
[2] Fac Med ABC, Dept Gynecol & Obstet, Human Reprod & Genet Ctr, Santo Andre, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Reproductive Health; v. 10, JUN 22 2013.
Citações Web of Science: 4
Resumo

Background: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). Methods: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. Results: The paraoxonase activity were 191.29 +/- 22.41 U/l in women with minimal/mild endometriosis and 224.85 +/- 21.50 U/l in women with moderate/ severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 +/- 4.61 U/l in women with minimal/mild endometriosis and 90.78 +/- 3.43 U/l in moderate/ severe disease (P = 0.888). Conclusions: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis. (AU)

Processo FAPESP: 13/12427-9 - There is no relationship between paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study
Beneficiário:Bianca Alves Vieira Bianco
Linha de fomento: Auxílio à Pesquisa - Publicações científicas - Artigo