Osteonecrosis of the mandible associated with bevacizumab therapy

Autor(es)

Santos-Silva, Alan Roger ^{[1, 2]} ; Belizario Rosa, Giuliano Augusto ^[1] ; de Castro Junior, Gilberto ^[3] ; Dias, Reinaldo Brito ^[4] ; Prado Ribeiro, Ana Carolina ^[1] ; Brandao, Thais Bianca ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, ICESP, Serv Dent Oncol, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Semiol Area, Dept Oral Diag, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, ICESP, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dent Sch, Dept Bucomaxillofacial Prosthesis, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 115, n. 6, p. E32-E36, JUN 2013.
• Citações Web of Science: 31

Resumo

Bevacizumab is a humanized antibody that blocks vascular endothelial growth factor and is of great value for the treatment of advanced cancer. Several adverse effects following its administration have been reported. To date, only 8 cases of osteonecrosis of the jaws associated with bevacizumab (without any association with bisphosphonates) have been reported. The aim of this article was to describe an original case of bevacizumab-related osteonecrosis of the jaw. A 61-year-old man diagnosed with advanced renal cell carcinoma was undergoing treatment with intravenous bevacizumab and temsirolimus when he spontaneously developed mandible osteonecrosis, which resolved after 3 months of conservative management. The present case reinforces recent speculation that the anti-angiogenic properties of bevacizumab may represent a potential new source of osteonecrosis of the jaws in patients undergoing cancer treatment. Multidisciplinary teams in cancer care should be aware of the possible association between osteonecrosis of the jaw and bevacizumab therapy. (AU)

• Processo FAPESP: 12/06138-1 - Estudo prospectivo da incidência de trismo induzido por radioterapia em pacientes com carcinoma espinocelular de boca
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular