| Texto completo | |
| Autor(es): |
Machado, Carla da Silva
[1]
;
Mendonca, Leonardo Meneghin
[1]
;
Venancio, Vinicius de Paula
[1]
;
Pires Bianchi, Maria Lourdes
[1]
;
Greggi Antunes, Lusania Maria
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Clin Toxicol & Bromatol Anal, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NeuroToxicology; v. 36, p. 10-16, MAY 2013. |
| Citações Web of Science: | 10 |
| Resumo | |
The purpose of this study was to investigate the neuroprotective effect of a water-soluble formulation of coenzyme Q10 (WS-CoQ10) in PC12 cells exposed to cisplatin, a chemotherapeutic agent with a dose-limiting factor due to neurotoxicity. In the cytokinesis-block micronucleus cytome assay (CBMN Cyt), WS-CoQ10 (at concentrations of 0.1, 0.5 and 1.0 mu g mL(-1)) protected PC12 cells from cisplatin-induced DNA damage (0.1 mu g mL(-1)), reducing the frequency of micronuclei (MNi) and nuclear buds (NBUDs). WS-CoQ10 did not alter the mRNA expression levels of Tp53 (at a concentration of 1.0 mu g mL(-1)) and exhibited neuroprotective activity by stimulating cisplatin-inhibited neurite outgrowth in nerve growth factor (NGF)-differentiated PC12 cells (at a concentration of 0.1 mu g mL(-1)). In conclusion, WS-CoQ10 protected the PC12 cells from cisplatin-induced DNA damage and neurotoxicity. Moreover, the neuroprotective effects of WS-CoQ10 suggest a possible application in chemotherapeutic protocols. (c) 2013 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 08/53947-7 - Neurotoxicidade induzida pelo quimioterápico cisplatina: possíveis efeitos citoprotetores dos antioxidantes da dieta curcumina e coenzima Q10 |
| Beneficiário: | Lusânia Maria Greggi Antunes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 09/11061-5 - Possíveis efeitos citoprotetores do antioxidante da dieta Coenzima Q10 em modelo de células neuronais |
| Beneficiário: | Carla da Silva Machado |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |