Corticotropin-releasing hormone-like immunoreactivity in the brain of the snake Bothrops jararaca

Autor(es)

Silveira, P. F. ^[1] ; Breno, M. C. ; Puorto, G. ; Martín del Río, M. P. ; Mancera, J. M.

Afiliação do(s) autor(es)

^[1] São Paulo (Estado). Secretaria de Estado da Saúde. Instituto Butantan - Brasil

• Tipo de documento: Artigo Científico
• Fonte: The Histochemical Journal; v. 33, n. 11/12, p. 685-694, 2001.
• Área do conhecimento: Ciências Biológicas - Fisiologia
• Assunto(s): Piracicaba (SP) Córtex cerebral Sistema hipotálamo-hipofisário Hormônio liberador de corticotrofina Serpentes Bothrops jararaca

Resumo

The distribution of corticotropin-releasing hormone in the brain of the snake Bothrops jararaca was studied immunohistochemically. Immunoreactive neurons were detected in telencephalic, diencephalic and mesencephalic areas such as dorsal cortex, subfornical organ, paraventricular nucleus, recessus infundibular nucleus, nucleus of the oculomotor nerve and nucleus of the trigeminal nerve. Immunoreactive fibres ran along the hypothalamo-hypophysial tract to end in the outer layer of the median eminence and the neural lobe of the hypophysis. In general, immunoreactive fibres occurred in the same places of immunoreactive neurons. In addition, immunoreactive fibres were observed in the septum, amygdala, lamina terminalis, supraoptic nucleus, nucleus of the paraventricular organ, ventromedial hypothalamic nucleus and interpeduncular nucleus. These results indicate that, as for other vertebrates, corticotropin-releasing hormone in B. jararaca brain, besides being a releasing hormone, may also act as a central neurotransmitter and/or neuromodulator. (AU)

• Processo FAPESP: 97/13262-9 - Balanço hidromineral e distribuição central de vasotocina (avt), mesotocina (MT), hormônio liberador de corticotrofina (CRF), e de leu-,arg-,asp- e cys-aminopeptidases
• Beneficiário: Paulo Flávio Silveira
• Modalidade de apoio: Bolsas no Exterior - Pesquisa