| Texto completo | |
| Autor(es): |
Fernandes, Daniara Cristina
;
Regasini, Luis Octávio
;
Vellosa, José Carlos Rebuglio
;
Pauletti, Patrícia Mendonça
;
Castro-Gamboa, Ian
;
Bolzani, Vanderlan Silva
;
Oliveira, Olga Maria Mascarenhas
;
Silva, Dulce Helena Siqueira
[8]
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Chemical & Pharmaceutical Bulletin; v. 56, n. 5, p. 723-726, May 2008. |
| Área do conhecimento: | Ciências Exatas e da Terra - Química |
| Assunto(s): | Flavonas Fabaceae Pterogyne nitens Peroxidase Antioxidantes Radicais livres |
| Resumo | |
Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. (AU) | |
| Processo FAPESP: | 04/07932-7 - Busca de compostos naturais antitumorais, antioxidantes, antiinflamatórios, antidiabéticos, inibidores de acetilcolinesterase e mieloperoxidase no Cerrado e na Mata Atlântica |
| Beneficiário: | Dulce Helena Siqueira Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |