| Full text | |
| Author(s): |
Fernandes, Daniara Cristina
;
Regasini, Luis Octávio
;
Vellosa, José Carlos Rebuglio
;
Pauletti, Patrícia Mendonça
;
Castro-Gamboa, Ian
;
Bolzani, Vanderlan Silva
;
Oliveira, Olga Maria Mascarenhas
;
Silva, Dulce Helena Siqueira
[8]
Total Authors: 8
|
| Document type: | Journal article |
| Source: | Chemical & Pharmaceutical Bulletin; v. 56, n. 5, p. 723-726, May 2008. |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Abstract | |
Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. (AU) | |
| FAPESP's process: | 04/07932-7 - Search for potential antitumoral, antioxidant, antiinflammatory, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest |
| Grantee: | Dulce Helena Siqueira Silva |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |