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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: quantification with immunohistochemical for calcium-binding proteins

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Autor(es):
Ferrari, Danuza [1] ; Cysneiros, Roberta M. ; Scorza, Carla A. ; Arida, Ricardo M. ; Cavalheiro, Esper A. ; Almeida, Antonio-Carlos G. de ; Scorza, Fulvio A.
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Universidade Federal de São Paulo (UNIFESP). Campus São Paulo - Vila Clementino. Escola Paulista de Medicina - Brasil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: Epilepsy & Behavior; v. 13, n. 1, p. 36-42, July 2008.
Área do conhecimento: Ciências Biológicas - Fisiologia
Assunto(s):Imuno-histoquímica   Fármacos neuroprotetores   Vitamina D   Parvalbuminas   Pilocarpina   Ácidos graxos ômega-3   Hipocampo   Epilepsia   Traumatismos encefálicos
Resumo

To investigate whether n-3 polyunsaturated fatty acids (n-3 PUFAs) would promote different morphological changes in the hippocampal formation of rats with epilepsy, we performed an immunocytochemical study using parvalbumin (PV) and calretinin (CR) distribution as a marker. Animals subjected to the experimental model of epilepsy with a single dose of pilocarpine were randomly divided into the following groups: animals with epilepsy treated daily with vehicle (EV) and animals with epilepsy treated daily with 85 mg/kg n-3 PUFAs (EW). Control animals administered saline were also randomly divided into two other groups: animals treated daily with vehicle (CV) and animals treated daily with 85 mg/kg n-3 PUFAs (CW). A larger number of PV-positive neurons were observed in EW when compared with EV, CV, and CW. Similarly, there were significantly more CR-positive neurons in EW than in EV. These findings demonstrate that omega-3 fatty acids prevent status epilepticus-associated neuropathological changes in the hippocamal formation of rats with epilepsy. (AU)

Processo FAPESP: 04/08186-7 - Efeito do omega-3 no modelo de epilepsia induzido pela pilocarpina.
Beneficiário:Danuza Ferrari
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica