| Texto completo | |
| Autor(es): |
Ferrari, Danuza
[1]
;
Cysneiros, Roberta M.
;
Scorza, Carla A.
;
Arida, Ricardo M.
;
Cavalheiro, Esper A.
;
Almeida, Antonio-Carlos G. de
;
Scorza, Fulvio A.
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Universidade Federal de São Paulo (UNIFESP). Campus São Paulo - Vila Clementino. Escola Paulista de Medicina - Brasil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Epilepsy & Behavior; v. 13, n. 1, p. 36-42, July 2008. |
| Área do conhecimento: | Ciências Biológicas - Fisiologia |
| Assunto(s): | Imuno-histoquímica Fármacos neuroprotetores Vitamina D Parvalbuminas Pilocarpina Ácidos graxos ômega-3 Hipocampo Epilepsia Traumatismos encefálicos |
| Resumo | |
To investigate whether n-3 polyunsaturated fatty acids (n-3 PUFAs) would promote different morphological changes in the hippocampal formation of rats with epilepsy, we performed an immunocytochemical study using parvalbumin (PV) and calretinin (CR) distribution as a marker. Animals subjected to the experimental model of epilepsy with a single dose of pilocarpine were randomly divided into the following groups: animals with epilepsy treated daily with vehicle (EV) and animals with epilepsy treated daily with 85 mg/kg n-3 PUFAs (EW). Control animals administered saline were also randomly divided into two other groups: animals treated daily with vehicle (CV) and animals treated daily with 85 mg/kg n-3 PUFAs (CW). A larger number of PV-positive neurons were observed in EW when compared with EV, CV, and CW. Similarly, there were significantly more CR-positive neurons in EW than in EV. These findings demonstrate that omega-3 fatty acids prevent status epilepticus-associated neuropathological changes in the hippocamal formation of rats with epilepsy. (AU) | |
| Processo FAPESP: | 04/08186-7 - Efeito do omega-3 no modelo de epilepsia induzido pela pilocarpina. |
| Beneficiário: | Danuza Ferrari |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |