| Full text | |
| Author(s): |
Ferrari, Danuza
[1]
;
Cysneiros, Roberta M.
;
Scorza, Carla A.
;
Arida, Ricardo M.
;
Cavalheiro, Esper A.
;
Almeida, Antonio-Carlos G. de
;
Scorza, Fulvio A.
Total Authors: 7
|
| Affiliation: | [1] Universidade Federal de São Paulo (UNIFESP). Campus São Paulo - Vila Clementino. Escola Paulista de Medicina - Brasil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Epilepsy & Behavior; v. 13, n. 1, p. 36-42, July 2008. |
| Field of knowledge: | Biological Sciences - Physiology |
| Abstract | |
To investigate whether n-3 polyunsaturated fatty acids (n-3 PUFAs) would promote different morphological changes in the hippocampal formation of rats with epilepsy, we performed an immunocytochemical study using parvalbumin (PV) and calretinin (CR) distribution as a marker. Animals subjected to the experimental model of epilepsy with a single dose of pilocarpine were randomly divided into the following groups: animals with epilepsy treated daily with vehicle (EV) and animals with epilepsy treated daily with 85 mg/kg n-3 PUFAs (EW). Control animals administered saline were also randomly divided into two other groups: animals treated daily with vehicle (CV) and animals treated daily with 85 mg/kg n-3 PUFAs (CW). A larger number of PV-positive neurons were observed in EW when compared with EV, CV, and CW. Similarly, there were significantly more CR-positive neurons in EW than in EV. These findings demonstrate that omega-3 fatty acids prevent status epilepticus-associated neuropathological changes in the hippocamal formation of rats with epilepsy. (AU) | |