Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines

Autor(es)

Munari, Carla Carolina ^[1] ; de Oliveira, Pollyanna Francielli ^[1] ; Lima Campos, Jacqueline Costa ^[1] ; Lima Martins, Sabrina de Paula ^[1] ; Da Costa, Juliana Carvalho ^[2] ; Bastos, Jairo Kenupp ^[2] ; Tavares, Denise Crispim ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Medicines; v. 68, n. 1, p. 236-241, JAN 2014.
• Citações Web of Science: 32

Resumo

Natural products are some of the important sources of new anticancer drugs. The Brazilian flora is considered one of the most diverse in the word, although not many large-scale pharmacological and phytochemical studies have been conducted to date. With this in mind, in the present study we evaluated the antiproliferative activity of Solanum lycocarpum fruit glycoalkaloid extract (SL) and its major compounds, solamargine (SM) and solasonine (SS), against different tumor cell lines: murine melanoma (B16F10), human colon carcinoma (HT29), human breast adenocarcinoma (MCF-7), human cervical adenocarcinoma (HeLa), human hepatocellular liver carcinoma (HepG2) and human glioblastoma (MO59J, U343 and U251). The antiproliferative activity was evaluated using XTT assay and results were expressed as IC50. The most pronounced antiproliferative activity was observed for SM, with IC50 values ranging from 4.58 to 18.23 mu g/mL. The lowest IC50 values were observed against HepG2, being 9.60 mu g/mL for SL, 4.58 mu g/mL for SM and 6.01 mu g/mL for SS. Thus, SL, SM and SS demonstrated antiproliferative activity against the tumor cell lines tested, and were most effective against the HepG2 cell line. (AU)

• Processo FAPESP: 09/15871-1 - Avaliação das atividades citotóxica, antigenotóxica, antimutagênica e anticarcinogênica do Solanum lycocarpum e dos seus principais compostos em células de mamíferos in vitro e in vivo
• Beneficiário: Carla Carolina Munari
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/05732-4 - Estudo do potencial citotóxico e genotóxico do extrato de Solanum lycocarpum e dos seus compostos majoritários e sua influência sobre a genotoxicidade induzida por diferentes mutágenos
• Beneficiário: Denise Crispim Tavares Barbosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular