Amygdala enlargement occurs in patients with mesial temporal lobe epilepsy and hippocampal sclerosis with early epilepsy onset

Autor(es)

Coan, Ana C. ^[1] ; Morita, Marcia E. ^[1] ; Campos, Brunno M. ^[1] ; Bergo, Felipe P. G. ^[1] ; Kubota, Bruno Y. ^[1] ; Cendes, Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Neurol, Neuroimaging Lab, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy & Behavior; v. 29, n. 2, p. 390-394, NOV 2013.
• Citações Web of Science: 15

Resumo

Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is considered an electroclinical syndrome, and there is a debate whether it is a unique disease or an entity with distinct subtypes. Together with other mesial temporal structures, the amygdala is important in the epileptogenic network of patients with MTLE with HS. During automatic volumetric analysis of mesial structures in a group of 102 patients with MTLE with MRI signs of HS, we observed significant amygdala enlargement in 14 (14%) individuals compared to a group of 79 healthy subjects. The increased amygdala volume was contralateral to the epileptogenic zone and MRI signs of HS in 93% of these patients. Patients with MTLE with HS and enlarged amygdala had significantly earlier epilepsy onset than those without an increase of amygdala volumes. Mesial temporal lobe epilepsy with HS and enlarged amygdala may be a part of the spectrum of this condition. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 05/56578-4 - Centro multimodal de neuroimagens para estudos em epilepsia
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático
• Processo FAPESP: 09/54552-9 - Estudo da progressão de dano na epilepsia de lobo temporal mesial com ou sem sinais de esclerose hipocampal
• Beneficiário: Ana Carolina Coan
• Modalidade de apoio: Bolsas no Brasil - Doutorado