| Texto completo | |
| Autor(es): |
Sabino-Silva, Robinson
[1, 2, 3]
;
Okamoto, Maristela Mitiko
[1]
;
David-Silva, Aline
[1]
;
Mori, Rosana Cristina
[1]
;
Freitas, Helayne Soares
[1]
;
Machado, Ubiratan Fabres
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Fed Uberlandia, Inst Ciencias Biomed, Area Fisiol & Farmacol, BR-38400902 Uberlandia, MG - Brazil
[3] Fed Univ Alagoas UFAL, Inst Biol Sci & Hlth, BR-57072970 Maceio, AL - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | DIABETOLOGY & METABOLIC SYNDROME; v. 5, OCT 24 2013. |
| Citações Web of Science: | 8 |
| Resumo | |
Background: Oral health complications in diabetes and hypertension include decreased salivary secretion. The sodium-glucose cotransporter 1 (SGLT1) protein, which transports 1 glucose/2 Na+/264 H2O molecules, is described in salivary glands. We hypothesized that changes in SGLT1 expression in the luminal membrane of ductal cell may be related to an altered salivary flow. Findings: By immunohistochemistry, we investigated SGLT1 expression in ductal cells of parotid and submandibular glands from Wistar Kyoto rats (WKY), diabetic WKY (WKY-D), spontaneously hypertensive rats (SHR) and diabetic SHR (SHR-D), as well as in parotid glands from WKY subjected to sympathetic stimulation, with or without previous propranolol blockade. Diabetes and hypertension decreased the salivary secretion and increased SGLT1 expression in the luminal membrane of ductal cells, and their association exacerbated the regulations observed. After 30 min of sympathetic stimulation, SGLT1 increased in the luminal membrane of ductal cells, and that was blocked by previous injection of propranolol. Conclusions: SGLT1 expression increases in the luminal membrane of salivary gland ductal cells and the salivary flow decreases in diabetic and hypertensive rats, which may be related to sympathetic activity. This study highlights the water transporter role of SGLT1 in salivary glands, which, by increasing ductal water reabsorption, may explain the hyposalivation of diabetic and hypertensive subjects. (AU) | |
| Processo FAPESP: | 07/50554-1 - Transportadores de glicose e Diabetes mellitus: contribuição ao conhecimento da regulação da glicemia e do desenvolvimento de complicações |
| Beneficiário: | Ubiratan Fabres Machado |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 09/16502-0 - Caracterização de núcleos centrais envolvidos na modulação da atividade simpática para as glândulas salivares: controle da concentração de glicose e do fluxo salivar em ratos hipertensos e diabéticos. |
| Beneficiário: | Robinson Sabino da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |