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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats

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Sabino-Silva, Robinson [1, 2, 3] ; Okamoto, Maristela Mitiko [1] ; David-Silva, Aline [1] ; Mori, Rosana Cristina [1] ; Freitas, Helayne Soares [1] ; Machado, Ubiratan Fabres [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Fed Uberlandia, Inst Ciencias Biomed, Area Fisiol & Farmacol, BR-38400902 Uberlandia, MG - Brazil
[3] Fed Univ Alagoas UFAL, Inst Biol Sci & Hlth, BR-57072970 Maceio, AL - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 8

Background: Oral health complications in diabetes and hypertension include decreased salivary secretion. The sodium-glucose cotransporter 1 (SGLT1) protein, which transports 1 glucose/2 Na+/264 H2O molecules, is described in salivary glands. We hypothesized that changes in SGLT1 expression in the luminal membrane of ductal cell may be related to an altered salivary flow. Findings: By immunohistochemistry, we investigated SGLT1 expression in ductal cells of parotid and submandibular glands from Wistar Kyoto rats (WKY), diabetic WKY (WKY-D), spontaneously hypertensive rats (SHR) and diabetic SHR (SHR-D), as well as in parotid glands from WKY subjected to sympathetic stimulation, with or without previous propranolol blockade. Diabetes and hypertension decreased the salivary secretion and increased SGLT1 expression in the luminal membrane of ductal cells, and their association exacerbated the regulations observed. After 30 min of sympathetic stimulation, SGLT1 increased in the luminal membrane of ductal cells, and that was blocked by previous injection of propranolol. Conclusions: SGLT1 expression increases in the luminal membrane of salivary gland ductal cells and the salivary flow decreases in diabetic and hypertensive rats, which may be related to sympathetic activity. This study highlights the water transporter role of SGLT1 in salivary glands, which, by increasing ductal water reabsorption, may explain the hyposalivation of diabetic and hypertensive subjects. (AU)

FAPESP's process: 07/50554-1 - Glucose transporters and diabetes mellitus: contribution to the knowledge of glycemic control and chronic diseases development
Grantee:Ubiratan Fabres Machado
Support type: Research Projects - Thematic Grants
FAPESP's process: 09/16502-0 - Characterization of central nuclei involved in sympathetic activity modulation to salivary glands: control of salivary glucose concentration and flux in hypertensive and diabetic rats.
Grantee:Robinson Sabino da Silva
Support type: Scholarships in Brazil - Post-Doctorate