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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Would right atrial stretch inhibit sodium intake following GABA(A) receptor activation in the lateral parabrachial nucleus?

Texto completo
Autor(es):
Shimoura, Caroline Gusson [1] ; Barbosa, Silas Pereira [2] ; Menani, Jose Vanderlei [2] ; Fratucci De Gobbi, Juliana Irani [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Dept Physiol, Inst Biosci, BR-18618000 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Neuroscience Letters; v. 553, p. 121-125, OCT 11 2013.
Citações Web of Science: 1
Resumo

The knowledge of the mechanisms underlying circulating volume control may be achieved by stretching a balloon placed at the junction of the superior vena cava-right atrial junction (SVC-RAJ). We investigated whether the inflation of a balloon at the SVC-RAJ inhibits the intake of 0.3 M NaCl induced by GABA(A) receptor activation in the lateral parabrachial nucleus (LPBN) in euhydrated and satiated rats. Male Wistar rats (280-300 g) with bilateral stainless steel LPBN cannulae and balloons implanted at the SVC-RAJ were used. Bilateral injections of the GABA(A) receptor agonist muscimol (0.5 eta mol/0.21) in the LPBN with deflated balloons increased intake of 0.3 M NaCl (30.1 +/- 3.9 vs. saline: 2.2 +/- 0.7) ml/210 min, n = 8) and water (17.7 +/- 1.9 vs. saline: 2.9 +/- 0.5 ml/210 min). Conversely, 0.3 M NaCl (27.8 +/- 2.1 ml/210 min) and water (22.8 +/- 2.3 ml/210 min) intake were not affected in rats with inflated balloons at the SVC-RAJ. The results show that sodium and water intake induced by muscimol injected into the LPBN was not affected by balloon inflation at the SVC-RAJ. We suggest that the blockade of LPBN neuronal activity with muscimol injections impairs inhibitory mechanisms activated by signals from cardiopulmonary volume receptors determined by balloon inflation. (C) 2013 The Authors. Published by Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 07/53963-0 - Participação glutamatérgica no núcleo parabraquial na regulação osmótica
Beneficiário:Juliana Irani Fratucci de Gobbi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/50949-1 - Mecanorreceptores cardíacos e receptores GABAérgicos: haveria integração no núcleo parabraquial lateral para a ingestão de sódio?
Beneficiário:Caroline Gusson Shimoura
Linha de fomento: Bolsas no Brasil - Iniciação Científica