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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection

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Autor(es):
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Mendoza Lopez, Rossana Veronica [1, 2] ; Levi, Jose Eduardo [3] ; Eluf-Neto, Jose [4] ; Koifman, Rosalina Jorge [5] ; Koifman, Sergio [5] ; Curado, Maria Paula [6, 7] ; Michaluart-Junior, Pedro [8] ; Alves Figueiredo, David Livingstone [9] ; Saggioro, Fabiano Pinto [9] ; de Carvalho, Marcos Brasilino [10] ; Kowalski, Luiz Paulo [11] ; Abrahao, Marcio [12] ; de Gois-Filho, Francisco [13] ; Tajara, Eloiza Helena [14] ; Waterboer, Tim [15] ; Boffetta, Paolo [16, 6] ; Brennan, Paul [17] ; Wuensch-Filho, Victor [1]
Número total de Autores: 18
Afiliação do(s) autor(es):
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[1] Univ Sao Paulo, Fac Saude Publ, BR-01246904 Sao Paulo - Brazil
[2] Hosp Canc Barretos, Inst Ensino & Pesquisa, Barretos - Brazil
[3] Univ Sao Paulo, Inst Med Trop, BR-01246904 Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, BR-01246904 Sao Paulo - Brazil
[5] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro - Brazil
[6] Int Prevent Res Inst, Lyon - France
[7] Hosp Araujo Jorge, Goiania - Brazil
[8] Univ Sao Paulo, Fac Med, Hosp Clin, BR-01246904 Sao Paulo - Brazil
[9] Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, BR-14049 Ribeirao Preto - Brazil
[10] Hosp Heliopolis, Sao Paulo - Brazil
[11] Hosp Canc AC Camargo, Sao Paulo - Brazil
[12] Univ Fed Sao Paulo, Hosp Sao Paulo, Sao Paulo - Brazil
[13] Inst Canc Arnaldo Viera Carvalho, Sao Paulo - Brazil
[14] Fac Med Sao Jose Rio Preto, Sao Paulo - Brazil
[15] German Canc Res Ctr, Heidelberg - Germany
[16] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY - USA
[17] Int Agcy Res Canc, F-69372 Lyon - France
Número total de Afiliações: 17
Tipo de documento: Artigo Científico
Fonte: CANCER CAUSES & CONTROL; v. 25, n. 4, p. 461-471, APR 2014.
Citações Web of Science: 31
Resumo

The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series. This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. In a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan-Meier method and Cox regression. Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. The presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. The death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative. Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma. (AU)

Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 09/52031-1 - Papilomavírus humano e prognóstico de tumores de cabeça e pescoço
Beneficiário:Victor Wünsch Filho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/50733-6 - Papilomavírus humano e prognóstico de tumores de cabeça e pescoço
Beneficiário:Rossana Verónica Mendoza López
Linha de fomento: Bolsas no Brasil - Doutorado