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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

HIF-1alpha Expression Profile in Intratumoral and Peritumoral Inflammatory Cells as a Prognostic Marker for Squamous Cell Carcinoma of the Oral Cavity

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Autor(es):
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Mendes, Suzanny Oliveira [1] ; dos Santos, Marcelo [1, 2] ; Peterle, Gabriela Tonini [1] ; Maia, Lucas de Lima [1] ; Stur, Elaine [1] ; Agostini, Lidiane Pignaton [1] ; de Carvalho, Marcos Brasilino [3] ; Tajara, Eloiza Helena [4] ; Louro, Iuri Drumond [1] ; Trivilin, Leonardo Oliveira [1] ; Alvares da Silva-Conforti, Adriana Madeira [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Fed Espirito Santo, Programa Pos Grad Biotecnol Renorbio, Vitoria, ES - Brazil
[2] Univ Fed Rio Grande do Norte, Dept Med, Caico, RN - Brazil
[3] Hosp Heliopolis, Lab Biol Mol, Sao Paulo - Brazil
[4] Fac Med Sao Jose do Rio Preto, Dept Biol Mol, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 9, n. 1 JAN 9 2014.
Citações Web of Science: 8
Resumo

The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1alpha subunit is stabilized in hypoxia conditions, creating the HIF-1 nuclear transcription factor. In inflammatory cells, high HIF-1alpha expression induces lymphocytic immunosuppression, decreasing tumoral antigen recognition, which promotes tumor growth. The present work investigated the relationship between HIF-1alpha expression in lymphocytes populating the intratumoral and peritumoral region of 56 patients with oral cancer. Our data indicates a prognostic value for this expression. High HIF-1alpha expression in peritumoral inflammatory cells is significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1alpha expression in tumoral inflammatory cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1alpha expression in peritumoral cells correlates with worse prognosis, independently of intratumoral expression. Low HIF-1alpha in tumor margins and high expression in the tumor was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low expression in tumor and tumor margins. Our results suggest that HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker. (AU)

Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático