| Full text | |
| Author(s): Show less - |
Mendes, Suzanny Oliveira
[1]
;
dos Santos, Marcelo
[1, 2]
;
Peterle, Gabriela Tonini
[1]
;
Maia, Lucas de Lima
[1]
;
Stur, Elaine
[1]
;
Agostini, Lidiane Pignaton
[1]
;
de Carvalho, Marcos Brasilino
[3]
;
Tajara, Eloiza Helena
[4]
;
Louro, Iuri Drumond
[1]
;
Trivilin, Leonardo Oliveira
[1]
;
Alvares da Silva-Conforti, Adriana Madeira
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Fed Espirito Santo, Programa Pos Grad Biotecnol Renorbio, Vitoria, ES - Brazil
[2] Univ Fed Rio Grande do Norte, Dept Med, Caico, RN - Brazil
[3] Hosp Heliopolis, Lab Biol Mol, Sao Paulo - Brazil
[4] Fac Med Sao Jose do Rio Preto, Dept Biol Mol, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | PLoS One; v. 9, n. 1 JAN 9 2014. |
| Web of Science Citations: | 7 |
| Abstract | |
The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1alpha subunit is stabilized in hypoxia conditions, creating the HIF-1 nuclear transcription factor. In inflammatory cells, high HIF-1alpha expression induces lymphocytic immunosuppression, decreasing tumoral antigen recognition, which promotes tumor growth. The present work investigated the relationship between HIF-1alpha expression in lymphocytes populating the intratumoral and peritumoral region of 56 patients with oral cancer. Our data indicates a prognostic value for this expression. High HIF-1alpha expression in peritumoral inflammatory cells is significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1alpha expression in tumoral inflammatory cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1alpha expression in peritumoral cells correlates with worse prognosis, independently of intratumoral expression. Low HIF-1alpha in tumor margins and high expression in the tumor was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low expression in tumor and tumor margins. Our results suggest that HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker. (AU) | |
| FAPESP's process: | 04/12054-9 - Markers of aggressive behavior in head and neck tumors |
| Grantee: | Eloiza Helena Tajara da Silva |
| Support Opportunities: | Research Projects - Thematic Grants |