Impact of exercise training on redox signaling in cardiovascular diseases

Autor(es)

Campos, Juliane C. ^[1] ; Gomes, Katia M. S. ^[1] ; Ferreira, Julio C. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Food and Chemical Toxicology; v. 62, p. 107-119, DEC 2013.
• Citações Web of Science: 37

Resumo

Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of cardiovascular diseases such as ischemia-reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in cardiovascular diseases. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/14416-1 - Controle de qualidade de proteína na disfunção/atrofia muscular esquelética: papel do receptor beta2- adrenérgico
• Beneficiário: Juliane Cruz Campos
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/05765-2 - Contribuição da enzima aldeído desidrogenase 2 na progressão da insuficiência cardíaca
• Beneficiário: Julio Cesar Batista Ferreira
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores