Impact of exercise training on redox signaling in cardiovascular diseases

Author(s)

Campos, Juliane C. ^[1] ; Gomes, Katia M. S. ^[1] ; Ferreira, Julio C. B. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Anat, BR-05508000 Sao Paulo - Brazil

• Document type: Review article
• Source: Food and Chemical Toxicology; v. 62, p. 107-119, DEC 2013.
• Web of Science Citations: 36

Abstract

Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of cardiovascular diseases such as ischemia-reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in cardiovascular diseases. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/05765-2 - Contribution of aldehyde dehydrogenase 2 to heart failure development
• Grantee: Julio Cesar Batista Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 12/14416-1 - Protein quality control profile in skeletal muscle wasting: role of beta2- adrenergic receptor
• Grantee: Juliane Cruz Campos
• Support Opportunities: Scholarships in Brazil - Doctorate