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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The Structurally Related Auxin and Melatonin Tryptophan-Derivatives and their Roles in Arabidopsis thaliana and in the Human Malaria Parasite Plasmodium falciparum

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Autor(es):
Koyama, Fernanda C. [1, 2] ; Carvalho, Thais L. G. [3] ; Alves, Eduardo [1, 2] ; da Silva, Henrique B. [4] ; de Azevedo, Mauro F. [5] ; Hemerly, Adriana S. [3] ; Garcia, Celia R. S. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, BR-05508090 Sao Paulo - Brazil
[3] Univ Fed Rio de Janeiro, Inst Bioquim Med, Lab Biol Mol Plantas, BR-21941590 Rio De Janeiro - Brazil
[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Immunol, BR-05508900 Sao Paulo - Brazil
[5] Macfarlane Burnet Inst Med Res & Publ Hlth, Ctr Immunol, Melbourne, Vic 3004 - Australia
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Eukaryotic Microbiology; v. 60, n. 6, p. 646-651, NOV 2013.
Citações Web of Science: 25
Resumo

Indole compounds are involved in a range of functions in many organisms. In the human malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are able to modulate its intraerythrocytic cycle, increasing the schizont population as well as parasitemia, likely through ubiquitin-proteasome system (UPS) gene regulation. In plants, melatonin regulates root development, in a similar way to that described for indoleacetic acid, suggesting that melatonin and indoleacetic acid could co-participate in some physiological processes due to structural similarities. In the present work, we evaluate whether the chemical structure similarity found in indoleacetic acid and melatonin can lead to similar effects in Arabidopsis thaliana lateral root formation and P. falciparum cell cycle modulation, as well as in the UPS of gene regulation, by qRT-PCR. Our data show that P. falciparum is not able to respond to indoleacetic acid either in the modulation of the intraerythrocytic cycle or in the gene regulation mediated by the UPS as observed for melatonin. The similarities of these indole compounds are not sufficient to confer synergistic functions in P. falciparum cell cycle modulation, but could interplay in A. thaliana lateral root formation. (AU)

Processo FAPESP: 11/51295-5 - Genômica funcional em Plasmodium
Beneficiário:Célia Regina da Silva Garcia
Linha de fomento: Auxílio à Pesquisa - Temático