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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Structurally Related Auxin and Melatonin Tryptophan-Derivatives and their Roles in Arabidopsis thaliana and in the Human Malaria Parasite Plasmodium falciparum

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Author(s):
Koyama, Fernanda C. [1, 2] ; Carvalho, Thais L. G. [3] ; Alves, Eduardo [1, 2] ; da Silva, Henrique B. [4] ; de Azevedo, Mauro F. [5] ; Hemerly, Adriana S. [3] ; Garcia, Celia R. S. [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, BR-05508090 Sao Paulo - Brazil
[3] Univ Fed Rio de Janeiro, Inst Bioquim Med, Lab Biol Mol Plantas, BR-21941590 Rio De Janeiro - Brazil
[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Immunol, BR-05508900 Sao Paulo - Brazil
[5] Macfarlane Burnet Inst Med Res & Publ Hlth, Ctr Immunol, Melbourne, Vic 3004 - Australia
Total Affiliations: 5
Document type: Journal article
Source: Journal of Eukaryotic Microbiology; v. 60, n. 6, p. 646-651, NOV 2013.
Web of Science Citations: 23
Abstract

Indole compounds are involved in a range of functions in many organisms. In the human malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are able to modulate its intraerythrocytic cycle, increasing the schizont population as well as parasitemia, likely through ubiquitin-proteasome system (UPS) gene regulation. In plants, melatonin regulates root development, in a similar way to that described for indoleacetic acid, suggesting that melatonin and indoleacetic acid could co-participate in some physiological processes due to structural similarities. In the present work, we evaluate whether the chemical structure similarity found in indoleacetic acid and melatonin can lead to similar effects in Arabidopsis thaliana lateral root formation and P. falciparum cell cycle modulation, as well as in the UPS of gene regulation, by qRT-PCR. Our data show that P. falciparum is not able to respond to indoleacetic acid either in the modulation of the intraerythrocytic cycle or in the gene regulation mediated by the UPS as observed for melatonin. The similarities of these indole compounds are not sufficient to confer synergistic functions in P. falciparum cell cycle modulation, but could interplay in A. thaliana lateral root formation. (AU)

FAPESP's process: 11/51295-5 - Functional genomics in Plasmodium
Grantee:Célia Regina da Silva Garcia
Support Opportunities: Research Projects - Thematic Grants