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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association of nonalcoholic fatty Liver disease with cardiovascular risk factors in obese adolescents: The role of interdisciplinary therapy

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Autor(es):
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Sanches, Priscila L. [1] ; de Piano, Aline [1] ; Campos, Raquel M. S. [1] ; Carnier, June [1] ; de Mello, Marco T. [1, 2] ; Elias, Natalia [3] ; Fonseca, Francisco A. H. [4] ; Masquio, Deborah C. L. [5] ; da Silva, Patricia L. [6] ; Corgosinho, Flavia C. [1] ; Tock, Lian [7] ; Oyama, Lila M. [8] ; Tufik, Sergio [2, 3] ; Damaso, Ana R. [1, 5, 9]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Post Grad Program Nutr, BR-04020050 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, BR-04020050 Sao Paulo - Brazil
[3] Assoc Fund Incent Res, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Med, Div Cardiol, BR-04020050 Sao Paulo - Brazil
[5] Univ Fed Sao Paulo Santos, Post Grad Program Interdisciplinary Hlth Sci, Sao Paulo - Brazil
[6] Univ Fed Goias, Goiania, Go - Brazil
[7] Weight Sci, Sao Paulo - Brazil
[8] Univ Fed Sao Paulo, Dept Physiol, BR-04020050 Sao Paulo - Brazil
[9] Univ Fed Sao Paulo, Dept Biosci, BR-04020050 Sao Paulo - Brazil
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL LIPIDOLOGY; v. 8, n. 3, p. 265-272, JUN 2014.
Citações Web of Science: 21
Resumo

BACKGROUND: Obesity is associated with several cardiovascular risk factors, including nonalcoholic fatty liver disease (NAFLD). These risk factors can induce changes in the arteries such as an increase in the carotid intima-media thickness (cIMT), which contributes to the early development of atherosclerosis. OBJECTIVE: To determine whether NAFLD is associated with an atherogenic lipid profile, inflammatory markers, or cIMT in obese adolescents and to compare the effects of therapeutic lifestyle changes in NAFLD and non-NAFLD groups. METHODS: A total of 79 obese adolescents were divided into two groups: 33 NAFLD and 46 non-NAFLD. They were submitted to an interdisciplinary therapy involving diet exercise and psychological support during the course of 1 year. The cIMT and estimates of fat mass (liver, intra-abdominal, and subcutaneous) were determined ultrasonographically. Body composition, glucose, lipid profile, and adipokines were analyzed before and after the therapy. RESULTS: At baseline, only in the NAFLD group was the homeostasis model assessment of insulin resistance positively correlated with cIMT and triglyceride/high-density lipoprotein cholesterol ratio. Therapy was associated with an increase in adiponectin concentrations and reduced visceral fat, cIMT, leptin, and plasminogen activator inhibitor-1 concentrations, as well as the ratios of total cholesterol/high-density lipoprotein cholesterol and triglycerides/high-density lipoprotein cholesterol in both groups. Only in the non-NAFLD group did therapy result in a reduction in the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and increased high-density lipoprotein cholesterol concentration. CONCLUSIONS: In obese adolescents, NAFLD is associated with cardiovascular risk factors and inflammatory markers of atherosclerosis that were positively correlated with cIMT only in the NAFLD group. Nevertheless, the strength of the present study is that the interdisciplinary therapy effectively improved cIMT and other proinflammatory adipokines in both groups. (C) 2014 National Lipid Association. All rights reserved. (AU)

Processo FAPESP: 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN)
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular