Complete Nucleotide Sequences of Two bla(KPC-2)-Bearing IncN Plasmids Isolated from Sequence Type 442 Klebsiella pneumoniae Clinical Strains Four Years Apart

Autor(es):Mostrar menos -

Perez-Chaparro, Paula Juliana ^{[1, 2]} ; Cerdeira, Louise Teixeira ^{[1, 3]} ; Queiroz, Maise Gomes ^[4] ; Silva de Lima, Clayton Pereira ^[1] ; Levy, Carlos Emilio ^[5] ; Pavez, Monica ^[6] ; Lincopan, Nilton ^{[6, 7]} ; Goncalves, Evonnildo Costa ^{[1, 4]} ; Mamizuka, Elsa Masae ^[6] ; Mello Sampaio, Jorge Luiz ^{[6, 3]} ; Teixeira Nunes, Marcio Roberto ^[1] ; McCulloch, John Anthony ^{[6, 1, 4]}

Afiliação do(s) autor(es)

^[1] Minist Saude, SVS, Inst Evandro Chagas, Ctr Inovacoes Tecnol, Ananindeua, Para - Brazil

^[2] Univ Guarulhos, Ctr Posgrad & Pesquisa, Dept Periodontia, Sao Paulo - Brazil

^[3] Grp Fleury, Sao Paulo - Brazil

^[4] Fed Univ Para, Inst Ciencias Biol, Lab Tecnol Biomol, BR-66059 Belem, Para - Brazil

^[5] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, Campinas, SP - Brazil

^[6] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, LMDIAS, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Antimicrobial Agents and Chemotherapy; v. 58, n. 5, p. 2958-2960, MAY 2014.
• Citações Web of Science: 9

Resumo

We sequenced the oldest bla(KPC-2)-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN bla(KPC-2)-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to May 2005. (AU)

• Processo FAPESP: 13/12107-4 - Estudo da resistência heterogênea à vancomicina em Staphylococcus aureus através da genética comparativa de subpopulações de um isolado
• Beneficiário: John Anthony McCulloch
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/20915-0 - Análise metagenômica da microbiota periodontal subgengival em indivíduos com e sem doença periodontal
• Beneficiário: Paula Juliana Perez Chaparro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado