The effect of pH and fluoride concentration of liquid dentifrices on caries progression

Autor(es)

Baldini Cardoso, Cristiane de Almeida ^[1] ; Barros Mangueira, Dayane Franco ^[2] ; Kaneshiro Olympio, Kelly Polido ^[1] ; Magalhaes, Ana Carolina ^[1] ; Rios, Daniela ^[3] ; Honorio, Heitor Marques ^[3] ; Vilhena, Fabiano Vieira ^[1] ; Sampaio, Fabio Correia ^[2] ; Rabelo Buzalaf, Marilia Afonso ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, BR-17012901 Sao Paulo - Brazil

^[2] Univ Fed Paraiba, Hlth Sci Ctr, BR-58059900 Joao Pessoa, Paraiba - Brazil

^[3] Univ Sao Paulo, Bauru Dent Sch, Dept Pediat Dent Orthodont & Publ Hlth, BR-17012901 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 18, n. 3, p. 761-767, APR 2014.
• Citações Web of Science: 5

Resumo

This randomized clinical trial evaluated the effect of pH and fluoride concentration of liquid dentifrices (LD) on caries progression and fluoride uptake in the toenails of 2-4-year-old children. Schoolchildren living in a fluoridated area, with (A) or without (I) active caries lesions, were randomly allocated into three groups according to the LD they would use over 12 months: group 1 (n = 48-A/56-I): 550 mu g fluoride (F)/g, pH 4.5; group 2 (n = 56-A/48-I) 1,100 mu g F/g, pH 7.0; and group 3 (n = 52-A/55-I): 550 mu g F/g, pH 7.0. The number of lesions becoming active/cavities or inactive was clinically evaluated by determining progression or regression. Additionally, white spot lesions were evaluated by the quantitative light-induced fluorescence (QLF) method in 75 children. Toenail fluoride concentration was also evaluated. Data were analyzed by ANOVA and followed by Dunn's test or ANCOVA followed by Tukey's test (p < 0.05). Caries net increment followed a decreasing pattern according to the dentifrice used (G1 < G2 < G3), regardless caries activity, but significant differences were detected only for caries progression and net increment (G1 < G3) for the caries-active group when evaluated through visual inspection. For the regression, the values found for the three groups were more similar, without significant differences. QLF analysis detected no significant difference between groups 1 and 2, but they performed significantly better than group 3. A significantly lower toenail fluoride concentration was observed when children used the low-fluoride dentifrices. The low-fluoride acidic LD has good potential to prevent caries and reduce fluoride intake. The low-F acidic dentifrice combines the desirable characteristics of caries prevention and reduced fluoride intake-for a product to be used by children, regardless their caries status. (AU)

• Processo FAPESP: 10/11916-8 - Avaliação do efeito de dentifrícios experimentais na forma de gel, com crescentes concentrações de flúor, acidulados ou neutros, sobre a desmineralização do esmalte dentário bovino in vitro
• Beneficiário: Bianca Milo Lacerda
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/01944-4 - Efeito do pH e da concentração de flúor presente em dentifrícios líquidos no controle de cárie em área fluoretada: estudo clínico randomizado
• Beneficiário: Cristiane de Almeida Baldini Cardoso
• Modalidade de apoio: Bolsas no Brasil - Doutorado