Septic arthritis: immunopathogenesis, experimental models and therapy

Autor(es)

Colavite, Priscila Maria ^[1] ; Sartori, Alexandrina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 20, MAY 6 2014.
• Citações Web of Science: 16

Resumo

Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included. (AU)

• Processo FAPESP: 11/04323-3 - Impacto do uso de droga imunomoduladora no tratamento da artrite séptica por Staphylococcusa aureus
• Beneficiário: Priscila Maria Colavite Machado
• Modalidade de apoio: Bolsas no Brasil - Mestrado