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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Translational Neurorehabilitation Research in the Third World What Barriers to Trial Participation Can Teach Us

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Autor(es):
Anjos, Sarah M. [1] ; Cohen, Leonardo G. [2] ; Sterr, Annette [3] ; de Andrade, Karina N. F. [1] ; Conforto, Adriana B. [4, 1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Hosp Clin, Neurol Clin Div, Dept Neurol, Sao Paulo - Brazil
[2] NINDS, Human Cort Physiol & Stroke Rehabil Sect, NIH, Bethesda, MD 20892 - USA
[3] Univ Surrey, Sch Psychol, Guildford GU2 5XH, Surrey - England
[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: STROKE; v. 45, n. 5, p. 1495-1497, MAY 2014.
Citações Web of Science: 9
Resumo

Background and Purpose Most stroke rehabilitation studies have been performed in high-income countries. The aim of this study was to identify the main barriers for patient inclusion in a research protocol performed in Brazil. MethodsWe evaluated reasons for exclusion of patients in a pilot, randomized, double-blinded clinical trial of stroke rehabilitation. Descriptive statistical analysis was performed. ResultsOnly 5.6% of 571 screened patients were included. Recurrent stroke was responsible for exclusion of 45.4% of potentially eligible patients. ConclusionsRecurrent stroke represented a big barrier to enroll patients in the protocol. External validity of rehabilitation trials will benefit from definition of study criteria according to regional characteristics of patients, including rates of recurrent stroke. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01333579. (AU)

Processo FAPESP: 06/55504-0 - Ensaio clínico com estimulação magnética transcraniana em pacientes com acidente vascular cerebral isquêmico
Beneficiário:Adriana Bastos Conforto
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 10/15660-8 - Ensaio clínico com estimulação magnética transcraniana em pacientes com acidente vascular cerebral isquêmico
Beneficiário:Sarah Monteiro dos Anjos
Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico