Comparative Evaluation of Antiproliferative Effects of Brazilian Green Propolis, Its Main Source Baccharis dracunculifolia, and Their Major Constituents Artepillin C and Baccharin

Autor(es)

de Oliveira, Pollyanna Francielli ^[1] ; de Souza Lima, Ildercilio Mota ^[1] ; Munari, Carla Carolina ^[1] ; Bastos, Jairo Kenupp ^[2] ; da Silva Filho, Ademar Alves ^[3] ; Tavares, Denise Crispim ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, BR-14404600 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil

^[3] Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, Juiz De Fora, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Planta Medica; v. 80, n. 6, p. 490-492, APR 2014.
• Citações Web of Science: 4

Resumo

This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 +/- 4.5 mu g/mL for U343 and 44.9 +/- 7.1 mu g/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 +/- 2.9 for U343 and 13.0 +/- 1.5 mu g/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 +/- 0.5 mu g/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin. (AU)

• Processo FAPESP: 09/12019-2 - Avaliação in vivo e in vitro do potencial mutagênico/antimutagênico e genotóxico/antigenotóxico da baccharina, um importante composto químico da Baccharis dracunculifolia
• Beneficiário: Pollyanna Francielli de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/07211-6 - Estudo da atividade mutagênica e/ou antimutagênica da Baccharis dracunculifolia e do Artepelin C em células de mamíferos
• Beneficiário: Denise Crispim Tavares
• Modalidade de apoio: Auxílio à Pesquisa - Regular