Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

Autor(es)

Teixeira de Sousa, Maria da Gloria ^{[1, 2]} ; Belda, Jr., Walter ^[3] ; Spina, Ricardo ^[3] ; Lota, Priscila Ramos ^[3] ; Valente, Neusa Sakai ^[3] ; Brown, Gordon D. ^[4] ; Criado, Paulo Ricardo ^[3] ; Benard, Gil ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Med Invest, Unit 53, Div Clin Dermatol, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Med Mycol, Trop Med Inst, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Clin Hosp, Div Clin Dermatol, BR-05508 Sao Paulo - Brazil

^[4] Univ Aberdeen, Inst Med Sci, Aberdeen Fungal Grp, Aberdeen AB9 1FX - Scotland

• Tipo de documento: Artigo Científico
• Fonte: Clinical Infectious Diseases; v. 58, n. 12, p. 1734-1737, JUN 15 2014.
• Citações Web of Science: 32

Resumo

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy. (AU)

• Processo FAPESP: 10/52155-0 - Caracterizacao da resposta imune inata e adaptativa na infeccao pelo dermatofito trichophyton rubrum.
• Beneficiário: Maria da Gloria Sousa Stafocker
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado