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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Topical Application of Imiquimod as a Treatment for Chromoblastomycosis

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Author(s):
Teixeira de Sousa, Maria da Gloria [1, 2] ; Belda, Jr., Walter [3] ; Spina, Ricardo [3] ; Lota, Priscila Ramos [3] ; Valente, Neusa Sakai [3] ; Brown, Gordon D. [4] ; Criado, Paulo Ricardo [3] ; Benard, Gil [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Med Invest, Unit 53, Div Clin Dermatol, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Med Mycol, Trop Med Inst, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Clin Hosp, Div Clin Dermatol, BR-05508 Sao Paulo - Brazil
[4] Univ Aberdeen, Inst Med Sci, Aberdeen Fungal Grp, Aberdeen AB9 1FX - Scotland
Total Affiliations: 4
Document type: Journal article
Source: Clinical Infectious Diseases; v. 58, n. 12, p. 1734-1737, JUN 15 2014.
Web of Science Citations: 32
Abstract

Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy. (AU)