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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Saturated Fatty Acid Intake Can Influence Increase in Plasminogen Activator Inhibitor-1 in Obese Adolescents

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Autor(es):
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Masquio, D. C. L. [1] ; de Piano, A. [1] ; Campos, R. M. S. [1] ; Sanches, P. L. [1] ; Corgosinho, F. C. [1] ; Carnier, J. [1] ; Oyama, L. M. [1, 2] ; do Nascimento, C. M. P. O. [2, 1] ; de Mello, M. T. [3] ; Tufik, S. [3] ; Damaso, A. R. [4, 1, 5]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil
[5] Univ Fed Sao Paulo, Postgrad Program Interdisciplinary Hlth Sci, Santos, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Hormone and Metabolic Research; v. 46, n. 4, p. 245-251, APR 2014.
Citações Web of Science: 12
Resumo

The aim of this study was to verify if saturated fatty acid intake adjusted by tertiles can influence metabolic, inflammation, and plasminogen activator inhibitor-1 (PAI-1) in obese adolescents. Body mass, height, body mass index, waist circumference, blood pressure, and body composition of 108 obese adolescents were obtained. Fasting glucose, insulin, PAI-1, and CRP were determined. Insulin resistance was assessed by Homeostasis Model Assessment (HOMA-IR) and insulin sensitivity by Quantitative Insulin Sensitivity Check Index (QUICKI). Dietetic intake was estimated by a 3-day dietary record, and volunteers were divided according to consumption of saturated fatty acids: tertile 1 {[}Low Saturated Fatty Acid Intake (Low-SFA): <= 12.14 g], tertile 2 {[}Moderate Saturated Fatty Intake (Moderate SFA intake): 12.15-20.48 g], and tertile 3 {[}High Saturated Fatty Acid Intake (High-SFA Intake); >20.48 g]. Statistical analysis was performed using STATISTICA 7.0 software and the significance level was set at p < 0.05. The most important finding in the present study is that Moderate and High-SFA intakes presented significantly higher values of PAI-1 than Low-SFA Intake. PAI-1 was positively associated with saturated fatty intake, waist circumference, mean blood pressure, and HOMA-IR. SFA intake was predictor of PAI-1 independent of body fat, HOMA-IR and total-cholesterol. In addition, PAI-1 was an independent predictor of blood pressure. HOMA-IR and QUICKI presented significantly higher and lower, respectively, in High-SFA compared to Moderate-SFA intake. High-SFA influenced cardiovascular disease risks, since it increased PAI-1 and insulin resistance, and decreased insulin sensibility, leading to vicious cycle among food ingestion, pro-thrombotic state, and cardiovascular risks in obese adolescents. Supporting Information for this article is available online at http://www.thieme-connect.de/ejournals/toc/hmr (AU)

Processo FAPESP: 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN)
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular