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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Saturated Fatty Acid Intake Can Influence Increase in Plasminogen Activator Inhibitor-1 in Obese Adolescents

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Masquio, D. C. L. [1] ; de Piano, A. [1] ; Campos, R. M. S. [1] ; Sanches, P. L. [1] ; Corgosinho, F. C. [1] ; Carnier, J. [1] ; Oyama, L. M. [2, 1] ; do Nascimento, C. M. P. O. [1, 2] ; de Mello, M. T. [3] ; Tufik, S. [3] ; Damaso, A. R. [4, 1, 5]
Total Authors: 11
[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil
[5] Univ Fed Sao Paulo, Postgrad Program Interdisciplinary Hlth Sci, Santos, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Hormone and Metabolic Research; v. 46, n. 4, p. 245-251, APR 2014.
Web of Science Citations: 12

The aim of this study was to verify if saturated fatty acid intake adjusted by tertiles can influence metabolic, inflammation, and plasminogen activator inhibitor-1 (PAI-1) in obese adolescents. Body mass, height, body mass index, waist circumference, blood pressure, and body composition of 108 obese adolescents were obtained. Fasting glucose, insulin, PAI-1, and CRP were determined. Insulin resistance was assessed by Homeostasis Model Assessment (HOMA-IR) and insulin sensitivity by Quantitative Insulin Sensitivity Check Index (QUICKI). Dietetic intake was estimated by a 3-day dietary record, and volunteers were divided according to consumption of saturated fatty acids: tertile 1 {[}Low Saturated Fatty Acid Intake (Low-SFA): <= 12.14 g], tertile 2 {[}Moderate Saturated Fatty Intake (Moderate SFA intake): 12.15-20.48 g], and tertile 3 {[}High Saturated Fatty Acid Intake (High-SFA Intake); >20.48 g]. Statistical analysis was performed using STATISTICA 7.0 software and the significance level was set at p < 0.05. The most important finding in the present study is that Moderate and High-SFA intakes presented significantly higher values of PAI-1 than Low-SFA Intake. PAI-1 was positively associated with saturated fatty intake, waist circumference, mean blood pressure, and HOMA-IR. SFA intake was predictor of PAI-1 independent of body fat, HOMA-IR and total-cholesterol. In addition, PAI-1 was an independent predictor of blood pressure. HOMA-IR and QUICKI presented significantly higher and lower, respectively, in High-SFA compared to Moderate-SFA intake. High-SFA influenced cardiovascular disease risks, since it increased PAI-1 and insulin resistance, and decreased insulin sensibility, leading to vicious cycle among food ingestion, pro-thrombotic state, and cardiovascular risks in obese adolescents. Supporting Information for this article is available online at (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants