"Structured lipid containing behenic acid in obesity and inflammation".

• Grant number: 17/00457-1
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2017 - October 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Alessandra Gambero
• Grantee: Alessandra Gambero
• Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil
• Associated researchers: Gabriela Alves Macedo

Abstract

Structured lipids are triacylglycerols restructured in relation to their composition or distribution of fatty acids in the glycerol backbone in order to modify physicochemical or nutritional properties. Structured lipids containing behenic acid, a long chain saturated fatty acid, are partially absorbed and can act as inhibitors of pancreatic lipase in the intestine, reducing lipid absorption and caloric intake, resulting in a great potential in the dietary management of obese patients. In this project, a structured lipid obtained by enzymatic interesterification from the soya / olive / fully hydrogenated crambe oil blend will be evaluated about its ability to control postprandial "inflammation" when administered acutely and to cause changes in the gastrointestinal tract of mice fed with a normal and high-fat diet during long term. It will also be evaluated its anti-obesity effect compared to the orlistat drug using mice with obesity induced by standard high-fat diet. It is also intended to evaluate if the consumption of this structured lipid containing behenic acid is able to alter the inflammatory response, which is dependent on the formation of lipid mediators, such as prostaglandins D2 and leukotriene B4, using a model of colitis in mice. In addition to containing behenic acid distributed randomly in the glycerol backbone, this structured lipid presents mono- and polyunsaturated fatty acids (oleic and linoleic acid) that can play additional effects in the synthesis of inflammatory lipid mediators. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, REGINALDO MARQUES; ZARRICUETA, MELINA LUZZI; TAKETA MOREIRA, DEBORA KONO; DE MORAIS, THAINA RODRIGUES; RIZZARDI, KARINA FERREIRA; PARISOTTO, THAIS MANZANO; DE PADUA GANDRA, RENATA LUANA; ZUIN, JULIA CRISTINA; RABELO E PAIVA CARIA, CINTIA; MACEDO, JULIANA ALVES; et al. STRUCTURED LIPID CONTAINING BEHENIC ACID VERSUS ORLISTAT FOR WEIGHT LOSS: AN EXPERIMENTAL STUDY IN MICE. PHARMANUTRITION, v. 14, DEC 2020. (17/00457-1)

DA SILVA, REGINALDO MARQUES; TAKETA MOREIRA, DEBORA KONO; ZARRICUETA, MELINA LUZZI; RABELO E PAIVA CARIA, ANTIA; MACEDO, JULIANA ALVES; MACEDO, GABRIELA ALVES; GAMBERO, ALESSANDRA. The postprandial inflammatory response is attenuated by a dietary structured lipid containing behenic acid. Journal of Functional Foods, v. 58, p. 350-354, JUL 2019. (17/00457-1)