Effect of treadmill gait on bone markers and bone mineral density of quadriplegic subjects

Autor(es)

D.C.L. Carvalho ^[1] ; C.R. Garlipp ^[2] ; P.V. Bottini ^[3] ; S.H. Afaz ^[4] ; M.A. Moda ^[5] ; A. Cliquet Jr.

Afiliação do(s) autor(es)

^[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Ortopedia e Traumatologia

^[2] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Patologia Clínica

^[3] Universidade Estadual de Campinas. Hospital Universitário. Divisão de Patologia Clínica - Brasil

^[4] Universidade Estadual de Campinas. Hospital Universitário. Divisão de Patologia Clínica - Brasil

^[5] Universidade Estadual de Campinas. Hospital Universitário. Divisão de Patologia Clínica - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 39, n. 10, p. 1357-1363, 2006-10-00.

Resumo

Quadriplegic subjects present extensive muscle mass paralysis which is responsible for the dramatic decrease in bone mass, increasing the risk of bone fractures. There has been much effort to find an efficient treatment to prevent or reverse this significant bone loss. We used 21 male subjects, mean age 31.95 ± 8.01 years, with chronic quadriplegia, between C4 and C8, to evaluate the effect of treadmill gait training using neuromuscular electrical stimulation, with 30-50% weight relief, on bone mass, comparing individual dual-energy X-ray absorptiometry responses and biochemical markers of bone metabolism. Subjects were divided into gait (N = 11) and control (N = 10) groups. The gait group underwent gait training for 6 months, twice a week, for 20 min, while the control group did not perform gait. Bone mineral density (BMD) of lumbar spine, femoral neck, trochanteric area, and total femur, and biochemical markers (osteocalcin, bone alkaline phosphatase, pyridinoline, and deoxypyridinoline) were measured at the beginning of the study and 6 months later. In the gait group, 81.8% of the subjects presented a significant increase in bone formation and 66.7% also presented a significant decrease of bone resorption markers, whereas 30% of the controls did not present any change in markers and 20% presented an increase in bone formation. Marker results did not always agree with BMD data. Indeed, many individuals with increased bone formation presented a decrease in BMD. Most individuals in the gait group presented an increase in bone formation markers and a decrease in bone resorption markers, suggesting that gait training, even with 30-50% body weight support, was efficient in improving the bone mass of chronic quadriplegics. (AU)

• Processo FAPESP: 03/05856-9 - Efeito do treinamento de marcha induzida por estimulacao eletrica neuromuscular sobre a osteoporose em pacientes lesados medulares.
• Beneficiário: Alberto Cliquet Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/53530-0 - Monitorizacao da densidade mineral ossea e trofismo muscular por tecnicas de ressonancia magnetica e tomografia computadorizada duran te o treinamento de marcha induzida por estimulacao eletrica...
• Beneficiário: Daniela Cristina Carvalho de Abreu
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 96/12198-2 - Desenvolvimento de mecanismos, órgãos artificiais e biosensores na modulação, controle e comunicação em sistemas biomecânicos e de reabilitação
• Beneficiário: Alberto Cliquet Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático