Epidemiological and functional implications of molecular variants of human papillomavirus

Autor(es)

L. Sichero ^[1] ; L.L. Villa ^[2]

Afiliação do(s) autor(es)

^[1] Instituto Ludwig de Pesquisa sobre o Câncer - Brasil

^[2] Instituto Ludwig de Pesquisa sobre o Câncer - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 39, n. 6, p. 707-717, 2006-06-00.

Resumo

Human papillomavirus genomes are classified into molecular variants when they present more than 98% of similarity to the prototype sequence within the L1 gene. Comparative nucleotide sequence analyses of these viruses have elucidated some features of their phylogenetic relationship. In addition, human papillomavirus intratype variability has also been used as an important tool in epidemiological studies of viral transmission, persistence and progression to clinically relevant cervical lesions. Until the present, little has been published concerning the functional significance of molecular variants. It has been shown that nucleotide variability within the long control region leads to differences in the binding affinity of some cellular transcriptional factors and to the enhancement of the expression of E6 and E7 oncogenes. Furthermore, in vivo and in vitro studies revealed differences in E6 and E7 biochemical and biological properties among molecular variants. Nevertheless, further correlation with additional functional information is needed to evaluate the significance of genome intratypic variability. These results are also important for the development of vaccines and to determine the extent to which immunization with L1 virus-like particles of one variant could induce antibodies that cross-neutralize other variants. (AU)

• Processo FAPESP: 03/11410-3 - Papel da atividade transcricional de variantes de papilomavírus humano 16 e 18 na transformação maligna e no escape do sistema imune
• Beneficiário: Laura Cristina Sichero Vettorazzo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado