Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

Autor(es)

Natalia Manrique ^[1] ; Cassiano Costa Silva Pereira ^[2] ; Lourdes Maria Gonzáles Garcia ^[3] ; Samuel Micaroni ^[4] ; Antonio Augusto Ferreira de Carvalho ^[5] ; Sílvia Helena Venturoli Perri ^[6] ; Roberta Okamoto ^[7] ; Doris Hissako Sumida ^[8] ; Cristina Antoniali ^[9]

Afiliação do(s) autor(es)

^[1] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Pediatric and Community Dentistry - Brasil

^[2] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Surgery and Integrated Clinic - Brasil

^[3] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Basic Sciences - Brasil

^[4] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Basic Sciences - Brasil

^[5] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Pathology and Clinical Propedeutics - Brasil

^[6] Univ. Estadual Paulista. School of Veterinary Medicine. Department of Clinics, Surgery and Animal Reproduction - Brasil

^[7] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Clinics, Surgery and Animal Reproduction - Brasil

^[8] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Basic Sciences - Brasil

^[9] Univ. Estadual Paulista. School of Dentistry of Araçatuba. Department of Basic Sciences - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Oral Science; v. 20, n. 2, p. 218-221, 2012-04-00.

Resumo

Hypertension is one of the most important public health problems worldwide. If undiagnosed or untreated, this pathology represents a systemic risk factor and offers unfavorable conditions for dental treatments, especially those requiring bone healing. Objectives: The purpose of this study was to demonstrate, by analysis of bone mineral density (BMD), that the alveolar bone healing process is altered in spontaneously hypertensive rats (SHRs). Material and Methods: Wistar rats and SHRs were submitted to extraction of the upper right incisor and were euthanized 7, 14, 21, 28 and 42 days after surgery. Right maxillae were collected, radiographed and analyzed using Digora software. BMD was expressed as minimum (min), middle (med) and maximum (max) in the medium (MT) and apical (AT) thirds of the dental alveolus. Results: The results were compared across days and groups. Wistar showed difference in med and max BMD in the MT between 7 and 28 and also between 14 and 28 days. The AT exhibited significant difference in med and min BMD between 7 and 28 days, as well as difference in min BMD between 28 and 42 days. SHRs showed lower med BMD in the MT at 28 days when compared to 21 and 42 days. Differences were observed across groups in med and min BMD at day 28 in the MT and AT; and in max BMD at 14, 21 and 42 days in the MT. Conclusions: These results suggest that the alveolar bone healing process is delayed in SHRs comparing with Wistar rats. (AU)

• Processo FAPESP: 08/01893-0 - Avaliação do efeito do atenolol no processo de reparo alveolar em ratos espontaneamente hipertensos (shr)
• Beneficiário: Natalia Manrique Cursino
• Modalidade de apoio: Bolsas no Brasil - Mestrado