Estrogen receptors and function in the male reproductive system

Autor(es)

Magalhaes Lazari, Maria Fatima ^[1] ; Gameiro Lucas, Thais Fabiana ^[1] ; Yasuhara, Fabiana ^[1] ; Oliveira Gomes, Gisele Renata ^[1] ; Siu, Erica Rosanna ^[1] ; Royer, Carine ^[1] ; Ferreira Fernandes, Sheilla Alessandra ^[1] ; Porto, Catarina Segreti ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Farmacol, Setor Endocrinol Expt, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 53, n. 8, p. 923-933, NOV 2009.
• Citações Web of Science: 30

Resumo

A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ER alpha and ER beta, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. In addition to the well established transcriptional effects, estrogens can mediate rapid signaling, triggered within seconds or minutes. These rapid effects can be mediated by ESRs or the G protein-coupled estrogen receptor GPER, also known as GPR30. The effects of estrogen on cell proliferation, differentiation and apoptosis are often mediated by growth factors. The understanding of the cross-talk between androgen, estrogen and growth factors signaling pathways is therefore essential to understand the physiopathological mechanisms of estrogen action. In this review we focused on recent discoveries about the nature of the estrogen receptors, and on the signaling and function of estrogen in the male reproductive system. Arq Bras Endocrinol Metab. 2009;53(8):923-33 (AU)

• Processo FAPESP: 06/60406-7 - Caracterizacao do papel da relaxina e da modulacao estrogenica sobre a expressao genica em ducto deferente de rato.
• Beneficiário: Maria de Fátima Magalhães Lazari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/52471-6 - Mecanismo de ação não-genômica do estrógeno em célula de Sertoli de ratos
• Beneficiário: Catarina Segreti Porto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/56564-1 - Receptores estrogênicos: expressão, regulação, sinalização e função no sistema reprodutor masculino, mama e cérebro
• Beneficiário: Catarina Segreti Porto
• Modalidade de apoio: Auxílio à Pesquisa - Temático