Estrogen receptors and function in the male reproductive system

Author(s)

Magalhaes Lazari, Maria Fatima ^[1] ; Gameiro Lucas, Thais Fabiana ^[1] ; Yasuhara, Fabiana ^[1] ; Oliveira Gomes, Gisele Renata ^[1] ; Siu, Erica Rosanna ^[1] ; Royer, Carine ^[1] ; Ferreira Fernandes, Sheilla Alessandra ^[1] ; Porto, Catarina Segreti ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Farmacol, Setor Endocrinol Expt, Sao Paulo - Brazil

• Document type: Review article
• Source: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 53, n. 8, p. 923-933, NOV 2009.
• Web of Science Citations: 30

Abstract

A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ER alpha and ER beta, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. In addition to the well established transcriptional effects, estrogens can mediate rapid signaling, triggered within seconds or minutes. These rapid effects can be mediated by ESRs or the G protein-coupled estrogen receptor GPER, also known as GPR30. The effects of estrogen on cell proliferation, differentiation and apoptosis are often mediated by growth factors. The understanding of the cross-talk between androgen, estrogen and growth factors signaling pathways is therefore essential to understand the physiopathological mechanisms of estrogen action. In this review we focused on recent discoveries about the nature of the estrogen receptors, and on the signaling and function of estrogen in the male reproductive system. Arq Bras Endocrinol Metab. 2009;53(8):923-33 (AU)

• FAPESP's process: 08/56564-1 - Estrogen receptors: expression, regulation, signaling, and function in the male reproductive tract, breast, and brain
• Grantee: Catarina Segreti Porto
• Support Opportunities: Research Projects - Thematic Grants