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Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors

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Cunha, Isabela Werneck [1] ; Carvalho, Katia Candido [1] ; Martins, Waleska Keller [1] ; Marques, Sarah Martins [1] ; Muto, Nair Hideko [1] ; Falzoni, Roberto [1] ; Rocha, Rafael Malagoli [1] ; Aguiar, Jr., Samuel [1] ; Simoes, Ana C. Q. [2] ; Fahham, Lucas [2] ; Neves, Eduardo Jordao [2] ; Soares, Fernando Augusto [1] ; Lima Reis, Luiz Fernando [3]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Hosp Canc AC Camargo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Matemat & Estat, Sao Paulo - Brazil
[3] Hosp Sirio Libanes, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: TRANSLATIONAL ONCOLOGY; v. 3, n. 1, p. 23-U39, FEB 2010.
Citações Web of Science: 30

Soft tissue tumors represent a group of neoplasia with different histologic and biological presentations varying from benign, locally confined to very aggressive and metastatic tumors. The molecular mechanisms responsible for such differences are still unknown. The understanding of these molecular alterations mechanism will be critical to discriminate patients who need systemic treatment from those that can be treated only locally and could also guide the development of new drugs' against this tumors. Using 102 tumor samples representing a large spectrum of these tumors, we performed expression profiling and defined differentially expression genes that are likely to be involved in tumors that are locally aggressive and in tumors with metastatic potential. We described a set of 12 genes (SNRPD3, MEGF9, SPTAN-1, AFAP1L2, ENDOD1, SERPIN5, ZWINTAS, TOP2A, UBE2C, ABCF1, MCM2, and ARL6IP5) showing opposite expression when these two conditions were compared. These genes are mainly related to cell-cell and cell-extracellular matrix interactions and cell proliferation and might represent helpful tools for a more precise classification and diagnosis as well as potential drug targets. (AU)

Processo FAPESP: 98/14335-2 - Antonio Prudente Cancer Research Center
Beneficiário:Fernando Augusto Soares
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs