| Texto completo | |
| Autor(es): |
Ariga, Suely Kubo
[1]
;
Abatepaulo, Fatima Bernardes
[2]
;
Anna Melo, Edielle Sant
[3]
;
Velasco, Irineu Tadeu
[4]
;
da Silva, Fabiano Pinheiro
[5]
;
de Lima, Thais Martins
[6]
;
Soriano, Francisco Garcia
[7]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo. Dept Emergency Med
[2] Univ Sao Paulo. Dept Emergency Med
[3] Univ Sao Paulo. Dept Emergency Med
[4] Univ Sao Paulo. Dept Emergency Med
[5] Univ Sao Paulo. Dept Emergency Med
[6] Univ Sao Paulo. Dept Emergency Med
[7] Univ Sao Paulo. Dept Emergency Med
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Shock; v. 42, n. 2, p. 168-173, AUG 2014. |
| Citações Web of Science: | 2 |
| Resumo | |
The objective of this randomized animal study and laboratory investigation was to investigate whether lipopolysaccharide tolerance redirects neutrophil migration between organs. Male BALB/c mice received subcutaneous injections of lipopolysaccharide (1 mg/kg) for 5 days, followed by cecal ligation and puncture (CLP). Cytokines and adhesion molecules were measured after tolerance and CLP challenge. Increased numbers of neutrophils were observed in the peritoneal cavity of tolerant mice, which was associated with increased levels of adhesion molecules and chemokines. In contrast, nontolerant mice accumulated higher numbers of neutrophils in the lungs compared with those in the peritoneal cavity. Neutrophil function accessed by hydrogen peroxide production from neutrophils recovered from peritoneal cavity showed that tolerance increased the capacity to produce hydrogen peroxide. Mortality was reduced in tolerant animals. This study demonstrated that tolerance reduces leukocyte accumulation in the lung after CLP by redirecting neutrophils to the site of infection. (AU) | |
| Processo FAPESP: | 02/07430-6 - Alteracoes de expressao genica na sepse e tolerancia a lps: analise da participacao do oxido nitrico na regulacao genica da sepse. |
| Beneficiário: | Francisco Garcia Soriano |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |