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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women

Texto completo
Autor(es):
D'Elia, Priscila Queiroz [1] ; dos Santos, Aline Amaro [2] ; Bianco, Bianca [2, 3] ; Barbosa, Caio Parente [2, 3] ; Christofolini, Denise Maria [2, 3] ; Aoki, Tsutomu [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Fac Ciencias Med Santa Casa Sao Paulo, BR-01221020 Sao Paulo - Brazil
[2] Fac Med ABC, BR-09060650 Santo Andre - Brazil
[3] Inst Ideia Fertil Saude Reprod, BR-09060650 Santo Andre - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Reproductive BioMedicine Online; v. 28, n. 6, p. 733-738, JUN 2014.
Citações Web of Science: 7
Resumo

The aim of this study was to investigate the association between MTHFR gene polymorphisms and IVF outcomes in Brazilian women undergoing assisted reproduction treatment. A prospective study was conducted in the Human Reproduction Department at the ABC University School of Medicine and the Ideia Fertility Institute between December 2010 and April 2012. The patient population was 82 women undergoing assisted reproduction cycles. The MTHFR polymorphisms C677T and A1298C were evaluated and compared with laboratory results and pregnancy rates. The C677T variant was associated with proportions of mature (P = 0.006) and immature (P = 0.003) oocytes whereas the A1298C variant was associated with number of oocytes retrieved (P = 0.044). The polymorphisms, whether alone or in combination, were not associated with normal fertilization, good-quality embryo or clinical pregnancy rates. This study suggests that the number and maturity of oocytes retrieved may be related to the MTHFR polymorphisms C677T and A1298C. (C) 2014, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 10/16274-4 - Avaliação de polimorfismos genéticos em mulheres inférteis, sua correlação com a síntese de estradiol e homocisteína folicular e sérica e com resultados de reprodução assistida
Beneficiário:Caio Parente Barbosa
Linha de fomento: Auxílio à Pesquisa - Regular