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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MTHFR polymorphisms C677T and A1298C and associations with IVF outcomes in Brazilian women

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Author(s):
D'Elia, Priscila Queiroz [1] ; dos Santos, Aline Amaro [2] ; Bianco, Bianca [2, 3] ; Barbosa, Caio Parente [2, 3] ; Christofolini, Denise Maria [2, 3] ; Aoki, Tsutomu [1]
Total Authors: 6
Affiliation:
[1] Fac Ciencias Med Santa Casa Sao Paulo, BR-01221020 Sao Paulo - Brazil
[2] Fac Med ABC, BR-09060650 Santo Andre - Brazil
[3] Inst Ideia Fertil Saude Reprod, BR-09060650 Santo Andre - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Reproductive BioMedicine Online; v. 28, n. 6, p. 733-738, JUN 2014.
Web of Science Citations: 7
Abstract

The aim of this study was to investigate the association between MTHFR gene polymorphisms and IVF outcomes in Brazilian women undergoing assisted reproduction treatment. A prospective study was conducted in the Human Reproduction Department at the ABC University School of Medicine and the Ideia Fertility Institute between December 2010 and April 2012. The patient population was 82 women undergoing assisted reproduction cycles. The MTHFR polymorphisms C677T and A1298C were evaluated and compared with laboratory results and pregnancy rates. The C677T variant was associated with proportions of mature (P = 0.006) and immature (P = 0.003) oocytes whereas the A1298C variant was associated with number of oocytes retrieved (P = 0.044). The polymorphisms, whether alone or in combination, were not associated with normal fertilization, good-quality embryo or clinical pregnancy rates. This study suggests that the number and maturity of oocytes retrieved may be related to the MTHFR polymorphisms C677T and A1298C. (C) 2014, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/16274-4 - Evaluation of genetic polymorphisms in infertile women, its correlation with stradiol and homocysteine in follicular fluid and peripheral blood, and with human reproduction outcomes
Grantee:Caio Parente Barbosa
Support Opportunities: Regular Research Grants