| Texto completo | |
| Autor(es): |
Ibiapino, Amanda Laura
[1]
;
Seiceira, Rafael Cardoso
[2]
;
Pitaluga, Jr., Altivo
[3]
;
Trindade, Antonio Carlos
[4]
;
Ferreira, Fabio Furlan
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Fed Abc, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil
[2] Fiocruz MS, Farmanguinhos, Lab Solid State Studies LEES, BR-22775903 Rio De Janeiro - Brazil
[3] Univ Fed Rio de Janeiro, Real Time Proc & Chem Anal Dev Ctr NQTR, Inst Chem, BR-21941614 Rio De Janeiro - Brazil
[4] IFSP, BR-08673010 Suzano, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CrystEngComm; v. 16, n. 36, p. 8555-8562, SEP 28 2014. |
| Citações Web of Science: | 10 |
| Resumo | |
Rifampicin is a first-line drug widely used in the treatment of tuberculosis both in the intensive and in the treatment phase. In this work we characterized the crystal structure of form I of anhydrous rifampicin mainly by using X-ray powder diffraction data combined with the Rietveld method. Other complementary techniques such as Fourier transform infrared spectroscopy and thermal analysis were also employed. It crystallized in a monoclinic crystal system with space group C2 and the following unit cell parameters: a = 25.8846(2) angstrom, b = 14.2965(2) angstrom, c = 14.2796(2) angstrom, beta = 122.98(1)degrees, V = 4432.81(7) angstrom(3), Z = 4, Z' = 1 and rho(calc) = 1.23310(2) g cm(-3). A BFDH model was used to inspect the crystal morphology prediction, and great similarity with crystals observed on an optical microscope was found. The FTIR spectrum confirmed the results obtained by X-ray powder diffraction, which indicates that all the functional groups involved in H bonding are intramolecularly connected. This polymorphic form presented a thermal stability up to approximately 230 degrees C. (AU) | |
| Processo FAPESP: | 08/10537-3 - Estudo de polimorfos de fármacos cristalinos através da difração de raios X por policristais e do método de Rietveld |
| Beneficiário: | Fabio Furlan Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |