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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structural characterization of form I of anhydrous rifampicin

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Autor(es):
Ibiapino, Amanda Laura [1] ; Seiceira, Rafael Cardoso [2] ; Pitaluga, Jr., Altivo [3] ; Trindade, Antonio Carlos [4] ; Ferreira, Fabio Furlan [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Abc, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil
[2] Fiocruz MS, Farmanguinhos, Lab Solid State Studies LEES, BR-22775903 Rio De Janeiro - Brazil
[3] Univ Fed Rio de Janeiro, Real Time Proc & Chem Anal Dev Ctr NQTR, Inst Chem, BR-21941614 Rio De Janeiro - Brazil
[4] IFSP, BR-08673010 Suzano, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: CrystEngComm; v. 16, n. 36, p. 8555-8562, SEP 28 2014.
Citações Web of Science: 10
Resumo

Rifampicin is a first-line drug widely used in the treatment of tuberculosis both in the intensive and in the treatment phase. In this work we characterized the crystal structure of form I of anhydrous rifampicin mainly by using X-ray powder diffraction data combined with the Rietveld method. Other complementary techniques such as Fourier transform infrared spectroscopy and thermal analysis were also employed. It crystallized in a monoclinic crystal system with space group C2 and the following unit cell parameters: a = 25.8846(2) angstrom, b = 14.2965(2) angstrom, c = 14.2796(2) angstrom, beta = 122.98(1)degrees, V = 4432.81(7) angstrom(3), Z = 4, Z' = 1 and rho(calc) = 1.23310(2) g cm(-3). A BFDH model was used to inspect the crystal morphology prediction, and great similarity with crystals observed on an optical microscope was found. The FTIR spectrum confirmed the results obtained by X-ray powder diffraction, which indicates that all the functional groups involved in H bonding are intramolecularly connected. This polymorphic form presented a thermal stability up to approximately 230 degrees C. (AU)

Processo FAPESP: 08/10537-3 - Estudo de polimorfos de fármacos cristalinos através da difração de raios X por policristais e do método de Rietveld
Beneficiário:Fabio Furlan Ferreira
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores