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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structural characterization of form I of anhydrous rifampicin

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Author(s):
Ibiapino, Amanda Laura [1] ; Seiceira, Rafael Cardoso [2] ; Pitaluga, Jr., Altivo [3] ; Trindade, Antonio Carlos [4] ; Ferreira, Fabio Furlan [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Abc, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil
[2] Fiocruz MS, Farmanguinhos, Lab Solid State Studies LEES, BR-22775903 Rio De Janeiro - Brazil
[3] Univ Fed Rio de Janeiro, Real Time Proc & Chem Anal Dev Ctr NQTR, Inst Chem, BR-21941614 Rio De Janeiro - Brazil
[4] IFSP, BR-08673010 Suzano, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CrystEngComm; v. 16, n. 36, p. 8555-8562, SEP 28 2014.
Web of Science Citations: 10
Abstract

Rifampicin is a first-line drug widely used in the treatment of tuberculosis both in the intensive and in the treatment phase. In this work we characterized the crystal structure of form I of anhydrous rifampicin mainly by using X-ray powder diffraction data combined with the Rietveld method. Other complementary techniques such as Fourier transform infrared spectroscopy and thermal analysis were also employed. It crystallized in a monoclinic crystal system with space group C2 and the following unit cell parameters: a = 25.8846(2) angstrom, b = 14.2965(2) angstrom, c = 14.2796(2) angstrom, beta = 122.98(1)degrees, V = 4432.81(7) angstrom(3), Z = 4, Z' = 1 and rho(calc) = 1.23310(2) g cm(-3). A BFDH model was used to inspect the crystal morphology prediction, and great similarity with crystals observed on an optical microscope was found. The FTIR spectrum confirmed the results obtained by X-ray powder diffraction, which indicates that all the functional groups involved in H bonding are intramolecularly connected. This polymorphic form presented a thermal stability up to approximately 230 degrees C. (AU)

FAPESP's process: 08/10537-3 - Study of crystalline pharmaceuticals polymorphs by X-ray powder diffraction and the Rietveld method
Grantee:Fabio Furlan Ferreira
Support Opportunities: Research Grants - Young Investigators Grants