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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Blood Profile and Histology in Oral Infections Associated with Diabetes

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Autor(es):
Angelo Cintra, Luciano Tavares [1] ; da Silva Facundo, Aguinaldo Candido [1] ; Carrara Prieto, Annelise Katrine [1] ; Sumida, Doris Hissako [2] ; Narciso, Luis Gustavo [3] ; Mogami Bomfim, Suely Regina [3] ; Oliveira e Silva, Cleverson [4] ; Dezan-Junior, Eloi [1] ; Gomes-Filho, Joao Eduardo [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Endodont, Sao Paulo - Brazil
[2] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, Sao Paulo - Brazil
[3] Univ Estadual Paulista, UNESP, Dept Clin & Surg & Anim Reprod, Sao Paulo - Brazil
[4] UEM Univ Estadual Maringa, Maringa Dent Sch, Dept Periodont, Maringa, Parana - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ENDODONTICS; v. 40, n. 8, p. 1139-1144, AUG 2014.
Citações Web of Science: 12
Resumo

Introduction: We aimed to investigate the relationship between blood profile and histologic findings in both apical periodontitis (AP) and periodontal disease (PD) associated with diabetes. Methods: Wistar rats (N = 80) were assigned to the following 8 groups: control, AP, PD, AP associated with PD, diabetes, diabetes with AP, diabetes with PD, and diabetes with AP and PD. Diabetes mellitus (DM) was induced with streptozotocin, AP was induced by exposure to the oral environment, and PD was induced using periodontal ligature. After 30 days, blood samples were collected, and the rats were euthanized. Subsequently, the maxillae were processed for light microscopy. Hematologic examinations were conducted to determine the total number of erythrocytes and leukocytes, erythrocyte constant, and blood glucose level. One-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at P < .05. Results: A significant correlation was found between the histologic findings and blood parameters. Conclusions: In conclusion, diabetes accelerated the development and progression of AP and PD in the rats and caused an increase in the average erythrocyte volume as well as the leukocyte and neutrophil counts. Oral infections increase the total number of leukocytes, the number of neutrophils and lymphocytes, and blood glucose concentrations in DM rats. (AU)

Processo FAPESP: 12/02083-8 - Influência da infecção pulpar associada à diabetes no perfil sanguíneo e na quantificação das citocinas pró-inflamatórias TNF-±, IL-6, IL-17. análise histológica, hematológica e em órgãos de Ratos Wistar
Beneficiário:Luciano Tavares Angelo Cintra
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/04588-0 - Status antioxidante e estresse oxidativo sérico em ratos com lesão periapical isolada ou associada à diabetes
Beneficiário:Annelise Katrine Carrara Prieto
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 10/16999-9 - Efeito da diabetes no desenvolvimento da infecção pulpar e/ou periodontal. estudo histológico em ratos
Beneficiário:Annelise Katrine Carrara Prieto
Linha de fomento: Bolsas no Brasil - Iniciação Científica