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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Blood Profile and Histology in Oral Infections Associated with Diabetes

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Author(s):
Angelo Cintra, Luciano Tavares [1] ; da Silva Facundo, Aguinaldo Candido [1] ; Carrara Prieto, Annelise Katrine [1] ; Sumida, Doris Hissako [2] ; Narciso, Luis Gustavo [3] ; Mogami Bomfim, Suely Regina [3] ; Oliveira e Silva, Cleverson [4] ; Dezan-Junior, Eloi [1] ; Gomes-Filho, Joao Eduardo [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Endodont, Sao Paulo - Brazil
[2] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, Sao Paulo - Brazil
[3] Univ Estadual Paulista, UNESP, Dept Clin & Surg & Anim Reprod, Sao Paulo - Brazil
[4] UEM Univ Estadual Maringa, Maringa Dent Sch, Dept Periodont, Maringa, Parana - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF ENDODONTICS; v. 40, n. 8, p. 1139-1144, AUG 2014.
Web of Science Citations: 12
Abstract

Introduction: We aimed to investigate the relationship between blood profile and histologic findings in both apical periodontitis (AP) and periodontal disease (PD) associated with diabetes. Methods: Wistar rats (N = 80) were assigned to the following 8 groups: control, AP, PD, AP associated with PD, diabetes, diabetes with AP, diabetes with PD, and diabetes with AP and PD. Diabetes mellitus (DM) was induced with streptozotocin, AP was induced by exposure to the oral environment, and PD was induced using periodontal ligature. After 30 days, blood samples were collected, and the rats were euthanized. Subsequently, the maxillae were processed for light microscopy. Hematologic examinations were conducted to determine the total number of erythrocytes and leukocytes, erythrocyte constant, and blood glucose level. One-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at P < .05. Results: A significant correlation was found between the histologic findings and blood parameters. Conclusions: In conclusion, diabetes accelerated the development and progression of AP and PD in the rats and caused an increase in the average erythrocyte volume as well as the leukocyte and neutrophil counts. Oral infections increase the total number of leukocytes, the number of neutrophils and lymphocytes, and blood glucose concentrations in DM rats. (AU)

FAPESP's process: 10/16999-9 - Effect of diabetes on the development of pulp infection and/or periodontal disease. Histological study in rats.
Grantee:Annelise Katrine Carrara Prieto
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/04588-0 - Serum antioxidant status and serum oxidative stress in rats with periapical lesion alone or associated with diabetes.
Grantee:Annelise Katrine Carrara Prieto
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/02083-8 - Influence of pulpal infection associated with diabetes in the blood profile and, quantification of proinflammatory cytokines TNF-±, IL-6, IL-17. Microscopic analysis, blood measurement and study in organs of rats.
Grantee:Luciano Tavares Angelo Cintra
Support type: Regular Research Grants