Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia

Autor(es):Mostrar menos -

Amaral, Fernanda G. ^[1] ; Turati, Ariane O. ^[1] ; Barone, Mark ^[2] ; Scialfa, Julieta H. ^[1] ; Buonfiglio, Daniella do Carmo ^[1] ; Peres, Rafael ^[1] ; Peliciari-Garcia, Rodrigo A. ^[1] ; Afeche, Solange C. ^[3] ; Lima, Larissa ^[4] ; Scavone, Cristoforo ^[4] ; Bordin, Silvana ^[1] ; Reiter, Russel J. ^[5] ; Menna-Barreto, Luiz ^[2] ; Cipolla-Neto, Jose ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Physiol & Biophys, Neurobiol Lab, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508000 Sao Paulo - Brazil

^[3] Butantan Inst, Pharmacol Lab, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Lab Mol Neuropharmacol, Dept Pharmacol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil

^[5] UT Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Pineal Research; v. 57, n. 1, p. 67-79, AUG 2014.
• Citações Web of Science: 26

Resumo

Melatonin is a neurohormone that works as a nighttime signal for circadian integrity and health maintenance. It is crucial for energy metabolism regulation, and the diabetes effects on its synthesis are unresolved. Using diverse techniques that included pineal microdialysis and ultrahigh-performance liquid chromatography, the present data show a clear acute and sustained melatonin synthesis reduction in diabetic rats as a result of pineal metabolism impairment that is unrelated to cell death. Hyperglycemia is the main cause of several diabetic complications, and its consequences in terms of melatonin production were assessed. Here, we show that local high glucose (HG) concentration is acutely detrimental to pineal melatonin synthesis in rats both in vivo and in vitro. The clinically depressive action of high blood glucose concentration in melatonin levels was also observed in type 1 diabetes patients who presented a negative correlation between hyperglycemia and 6-sulfatoxymelatonin excretion. Additionally, high-mean-glycemia type 1 diabetes patients presented lower 6-sulfatoxymelatonin levels when compared to control subjects. Although further studies are needed to fully clarify the mechanisms, the present results provide evidence that high circulating glucose levels interfere with pineal melatonin production. Given the essential role played by melatonin as a powerful antioxidant and in the control of energy homeostasis, sleep and biological rhythms and knowing that optimal glycemic control is usually an issue for patients with diabetes, melatonin supplementation may be considered as an additional tool to the current treatment. (AU)

• Processo FAPESP: 04/06767-2 - O papel da melatonina no controle do metabolismo energético: interações hormonais, ações centrais e periféricas (pineal, obesidade, diabetes e envelhecimento)
• Beneficiário: José Cipolla Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 08/11026-2 - Ciclo vigília /sono em portadores de diabetes mellitus tipo 1
• Beneficiário: Luiz Silveira Menna Barreto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/52920-0 - O papel da melatonina no controle do metabolismo energético: ações centrais, periféricas e a regulação circadiana da função metabólica pineal, diabetes, obesidade e envelhecimento
• Beneficiário: José Cipolla Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático